IMPACT OF WEIGHT LOSS & EXERCISE ON KNEE OSTEOARTHRITIS

描述(摘自申请者的摘要)：苏珊·巴特利特博士有一个 减肥和运动方面的临床背景。她对临床工作的承诺 据说，她多年的研究投资证明了这一点 宾夕法尼亚大学肥胖研究小组，毕业归来 学校获得研究方法和干预方面的博士培训作为 临床心理学家，以及完成体重研究员资格 约翰·霍普金斯医学院的管理人员。膝关节骨关节炎(OA)是 这是影响美国数百万人的一项重大公共卫生挑战。肥胖 是干预的主要目标，因为它占膝盖的30% 骨性关节炎会加重症状，并与双侧受累等相关 疾病的快速发展。而美国风湿病学会 实践指南建议将适度减肥作为对症治疗，以 目前尚无已发表的临床试验研究减肥的影响 在膝盖骨上。体力活动也与减轻疼痛和 膝骨性关节炎患者的活动度增加，应纳入治疗 (ACR实践指南)。运动可能对超重特别有帮助 患有膝骨性关节炎的人，因为它是维持体重减轻的有效预测因子。 尽管对传统锻炼计划的坚持程度很低，但在 全天积累的哪种运动看起来是一个有希望的新方法 体力活动的方法。生活方式和体力活动 对健康和减肥都有好处。生活方式锻炼也可能会增强 通过增加活动选项和减少时间来锻炼忠诚度 障碍。间歇性的体力活动可能比持续的运动更可取 运动能减轻疼痛，避免受伤。 这项提案的主要目标是评估减肥的影响 以及生活方式锻炼对膝骨性关节炎的影响。要做到这一点，156 有症状的膝骨性关节炎的超重者将被随机接受 为期16周的计划：1)减肥+生活方式体育活动；或2) 健康教育(对照)。主要的结果衡量标准将是膝盖疼痛。 次要指标包括身体残疾、生活质量、工作表现 措施和长期坚持的行为改变。这项研究将提供 将行为改变整合到膝骨性关节炎治疗中的数据。

DESCRIPTION (Taken from the applicant's abstract): Dr. Susan Bartlett has a clinical background in weight loss and exercise. Her commitment to clinical research is said to be demonstrated by her investment of many years with the Obesity Research Group at the University of Pennsylvania, return to graduate school obtain Ph.D. training in research methodology and interventions as a clinical psychologist, as well as completion of a fellowship in Weight Management at the Johns Hopkins School of Medicine. Knee osteoarthritis (OA) is a major public health challenge affecting millions of people in the US. Obesity is a primary target for intervention since it accounts for up to 30% of knee OA, exacerbates symptoms and is associated with bi-lateral involvement and more rapid progression of the disease. While the American College of Rheumatology Practice Guidelines recommends modest weight loss as symptomatic therapy, to date no published clinical trials have investigated the impact of weight loss on knee OA. Physical activity has also been associated with pain reduction and increased mobility in individuals with knee OA and should included in treatment (ACR Practice Guidelines). Exercise may be especially helpful for overweight persons with knee OA as it is a potent predictor of maintenance of weight loss. Though adherence to traditional exercise programs has been poor, lifestyle in which exercise is accumulated throughout the day appears to be a promising new approach to physical activity. Lifestyle physical activity has been associated with both health and weight loss benefits. Lifestyle exercise may also enhance exercise adherence by increasing options to be active and reducing time barriers. Episodes of physical activity may be preferable to continuous exercise in reducing pain and avoiding injury. The primary objective of this proposal is to evaluate the impact of weight loss and lifestyle exercise on knee osteoarthritis. To accomplish this, 156 overweight persons with symptomatic knee OA will be randomized to receive a 16-week program of: 1 ) a weight loss + lifestyle physical activity; or 2) health education (control). The primary outcome measure will be knee pain. Secondary measures include physical disability, quality of life, performance measures and long-term adherence to behavior change. This study will provide data on integrating behavioral changes into the treatment of knee OA.