Phytoestrogens and innate immunity in ER deficient mice

这个项目的目标是确定范围和机制 植物雌激素(染料木素、Diadzein和大豆提取物)对先天的作用 通过雌激素受体依赖和独立的途径发挥免疫功能。这 目标将通过雌激素受体缺陷(ERKO)严重 联合免疫缺陷(SCID)小鼠细菌性炎症模型的建立 肠、肝、脾。假设雌激素和植物雌激素 信号是巨噬细胞和自然杀伤细胞的正向调节因子 功能。 具体地说，该项目将…… 1)确定雌激素受体α信号的丢失对 细菌引起的炎症。 2)确定雌激素受体β信号的丢失对 细菌引起的炎症。 3)确定雌激素受体α和β受体缺失的影响 细菌引起的炎症信号。 这个项目的私人投资者是D.马克·埃斯蒂斯，联合私人投资者是克里格·富兰克林。二 该项目的顾问是海伦·马伦和丹尼斯·卢班。所有这些都是 工作人员驻扎在密苏里大学哥伦比亚分校。这些网站是 UM-C？S园艺农林研究中心在纽约 富兰克林和密歇根大学S西南考察站。弗农。

The goal of this project is to determine the range and mechanism of action of phytoestrogens (genistein, diadzein and soy extracts) on innate immune function via estrogen receptor-dependent and independent pathways. This goal will be accomplished using estrogen receptor deficient (ERKO) severe combined immunodeficient (SCID) mouse models of bacterial inflammation in the gut, liver and spleen. The hypothesis is that estrogen and phytoestrogen signaling is a positive regulator of macrophage and natural killer cell function. Specifically, the project will... 1) Determine the effects of the loss of estrogen receptor alpha signaling on bacterial-induced inflammation. 2) Determine the effects of the loss of estrogen receptor beta signaling on bacterial-induced inflammation. 3) Determine the effects of the loss of estrogen receptors alpha and beta signaling on bacterial induced inflammation. The PI on this project is D. Mark Estes and the co-PI is Criag Franklin. Two consultants on the project are Helen Mullen and Dennis Lubahn. All of these personnel are based at the University of Missouri-Columbia. The sites for the research are the UM-C?s Horticulture and Agroforestery Research Center in New Franklin and the UM-C?s Southwest Research Station in Mt. Vernon.