Agilent 5973 GC/MS System

由美国国立卫生研究院资助的生物医学研究的进展需要随时可以使用气相色谱/质谱联用（GC/MS）进行常规分析。目前支持的将受益于新的GC/MS的项目包括：1)面向选择性有机合成新合成方法开发的研究。2)涉及合成具有生物学意义的结构复杂分子的程序。3)早期和晚期过渡金属配合物的新配体的合成，以及应用于有机分子选择性合成的金属配体加合物的性质和反应性的研究。4)电荷转移反应机理及光收集和小分子活化的仿生化学研究。5)针对新型抗疟药物的设计和合成的合成研究，以及细胞信号系统蛋白激酶c的有效激活剂ingenol的合成。这些多样化项目的成功和及时发展的关键需要是能够获得用户友好的常规GC/MS数据的仪器。我们目前缺乏这样的仪器对开展这些研究的能力产生了负面影响。这种关键的能力，以日常分析仪器的形式，是迫切需要的。

Advances in biomedical research funded by the NIH in our department require ready access to combined gas chromatography/mass spectrometry (GC/MS) for routine analyses. Currently supported projects that would benefit from a new GC/MS include: 1) Studies geared toward the development of new synthetic methods for selective organic synthesis. 2) Programs involved in the synthesis of structurally complex molecules of biological interest. 3) Synthesis of new ligands for both early and late transition metal complexes and the examination of the properties and reactivity of the resulting metal-ligand adducts as applied to the selective synthesis of organic molecules. 4) Mechanistic studies of charge transfer reactions as well as the biomimetic chemistry of light harvesting and small molecule activation. 5) Synthetic studies directed toward the design and synthesis of new antimalarials, and the synthesis of ingenol, a potent activator of the cell signaling system protein kinase C. A critical need for the successful and timely development of these diverse projects is access to an instrument for obtaining GC/MS data on a user-friendly, routine basis. Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed.