CATALYTIC PROCESSES FOR SELECTIVE ORGANIC SYTHESIS

描述：（申请人摘要）选择性催化方法 描述了有机合成。 有机镧系元素，第3族 有机金属化合物和第4族阳离子络合物将被用作 催化剂在广泛的过程中用于构建复合物 有机分子从相当简单，容易获得的前体。 一 有机金属配合物的家庭将被合成， 工艺中显著的反应性、选择性和催化转化率 概述。 这需要对金属、配体和， 在阳离子络合物的情况下，催化剂的反离子。 待开发的工艺预计将表现出高度的 区域选择性和非对映选择性。 长期目标是 开发用于不对称合成的手性非外消旋催化剂 有机分子 首先，要进行的化学反应将是 集中在新合成方法的基本方面。 然而，准备 获得通过这些方法产生的化合物将提供更有效的 和经济的手段，以生物活性材料的利益， 医药行业。 例如，可以对反应进行排序以 从简单的开始， 材料到最终产品。 此外，这些方法是 无害环境，因为它们以不产生副产品的方式进行， 生成（即，他们着手进行“原子经济”）。 若干不同 区域，都是由同一类有机金属催化的， 针对研究。 这些包括：1）氢化硅烷化和硼氢化 反应. 2)甲硅烷基金属化反应。 3)烯烃胺化反应。 4)聚烯烃、二烯炔、烯二炔等的环化反应。 包括顺序反应，其中环化通过以下终止： 甲硅烷基化、硼化、氢解或β-氢化物消除。

DESCRIPTION: (applicant's abstract) Catalytic processes for selective organic synthesis are described. Organolanthanides, group 3 organometallics, and group 4 cationic complexes will be utilized as catalysts in a wide range of processes for the construction of complex organic molecules from rather simple, readily available precursors. A family of organometallic complexes will be synthesized exhibiting significant reactivity, selectivity, and catalytic turnover in the processes outlined. This requires substantial "tuning" of the metal, the ligand, and, in the case of cationic complexes, the counterion of the catalyst. Processes to be developed are expected to exhibit a high degree of regioselectivity and diastereoselectivity. A long-term objective will be to develop chiral, nonracemic catalysts for use in asymmetric synthesis of organic molecules. At the outset, the chemistry to be carried out will be focused on fundamental aspects of the new synthetic methods. However, ready access to compounds generated by these methods will provide more efficient and economical means to biologically active materials of interest to the pharmaceutical industry. For example, the reactions can be sequenced to provide a dramatic increase in molecular complexity from simple starting materials to the final products. Furthermore, the methods are environmentally sound in that they proceed in a manner where no byproducts are generated (i.e., they proceed with "atom economy"). Several diverse areas, all catalyzed by the same class of organometallics, have been targeted for study. These include: 1) Hydrosilylation and hydroboration reactions. 2) Silylmetalation reactions. 3) Olefin amination reactions. 4) Cyclization reactions of polyolefins, dieneynes, enediynes, etc. involving sequential reactions wherein the cyclizations are terminated by silylation, boration, hydrogenolysis, or beta-hydride elimination.