Core--Clinical and pathologic data and specimens

临床核心的目的是为五个拟建项目中的三个项目提供ANCA肾小球肾炎（ANCA- gn）患者的病理数据、临床信息以及血液和组织样本。临床核心由五个已经存在的组成部分组成，并且具有持续建立和相互关联的工作关系。五个组成部分包括：1)北卡罗来纳大学肾脏病理学实验室；2)北卡罗来纳大学肾小球肾炎和血管炎；5)统计学家/流行病学家。通过共同努力，这个核心的组成部分已经建立了公开摘要和手稿的能力。UNC肾脏病理实验室每年评估约1500例肾活检标本，其中约15%来自UNCS肾小球肾炎。罗纳德·j·福尔克和j·查尔斯·珍妮特组成了一个名为GDCN的研究合作。GDCN的支柱是维持ANCA- GN患者登记。收集了自1986年以来诊断的250多名患者的临床信息。登记患者从出现症状一直随访到死亡。登记数据为手稿提供了关于临床表现、疾病关联、治疗反应、环境关联以及透析、死亡和疾病复发的预后标志物的信息。该中心将确定患者参与ANCA-GN研究中的环境因素（项目#5），并将对这些患者进行长期随访，以评估环境因素在疾病进展中的作用。登记处为收集血样提供了一个病人库。样本可以在UNC肾小球肾炎和血管炎诊所收集，并从GDCN收集血液样本。样本可以在UNC肾小球肾炎和血管炎诊所和GDCN实践中收集。在体外分析ANCA诱导的肾小球炎症（项目3）的各个阶段，许多患者都需要血液样本。综上所述，在疾病的各个临床阶段，核心将在识别患者、获取血液样本和临床信息方面发挥关键作用。该核心还将为统计分析提供支持。核心表现出协同工作的能力，能够满足项目的临床研究需求。

The purpose of the clinical core is to provide pathologic data, clinical information and blood and tissue samples on ANCA glomerulonephritis (ANCA-GN) patients for three of the five proposed projects. The clinical core consists of five components that already exist and that have an ongoing establish and interconnected working relationship. The five components include 1) the UNC Nephropathology Laboratory, 2) the UNC Glomerulonephritis and Vasculitis 5) a statistician/epidemiologist. Working together, the components of this core have established the ability to public abstracts and manuscripts. The UNC Nephropathology Laboratory evaluates approximately 1,500 renal biopsy specimens per year with approximately 15% from the UNCS Glomerulonephritis have joined together with Drs. Ronald J. Falk and J. Charles Jeanette of UNC to form a research collaboration called the GDCN. The mainstay of the GDCN has been the maintenance an ANCA- GN patient registry. Clinical information is collected on over 250 patients diagnosed since 1986. Registry patients are followed from the onset of symptoms until death. Registry data has provided information for manuscripts on clinical presentation, disease associations, treatment response, environmental associations, and on prognostic markers for dialysis, death and disease relapses. The core will identify patients for participation in the Environmental Factors in ANCA-GN study (Project #5) and will maintain long-term follow-up of these patients to evaluate the role of environmental factors in disease progression. The registry provides a pool of patients for collecting blood samples. Samples can be collected at the UNC Glomerulonephritis and Vasculitis Clinic and from the GDCN practices for collecting blood samples. Samples can be collected at the UNC Glomerulonephritis and Vasculitis Clinic and from the GDCN practices. Blood samples will be needed on numerous patients during various stages of Vitro Analysis of ANCA- Induced Glomerular Inflammation (Project 3). In summary, the core will play a critical role in identifying patients and obtaining blood samples and clinical information at these various clinical stages of the disease. The core will also provide support for statistical analysis. The core has demonstrated the ability to work collaboratively and can meet the clinical research needs of the program project.