CORE--SOLID TUMOR PHARMACOLOGY

描述(申请人提供)：实体瘤药理核心的功能如下 答：作为该计划临床前和临床药代动力学研究的一部分，对从动物和患者采集的生物标本中的药物和药物代谢物浓度进行量化分析。B.分析从临床前和临床药代动力学研究中获得的药代动力学数据，并根据本项目研究人员的要求，将适当的药代动力学和药效学模型与数据相匹配。C.对本计划项目6的临床试验的患者样本进行基因分型研究。D.维护实体肿瘤药理学核心分析数据的计算机数据库，并根据需要生成数据检索和报告。E.根据需要执行额外的特殊实验室程序，以支持本计划中包括的项目。

DESCRIPTION (provided by applicant): The functions of the Solid Tumor Pharmacology Core are to: A. Perform assays to quantitate drug and drug metabolite concentrations in biological specimens collected from animals and patients as part of preclinical and clinical pharmacokinetic studies within this program. B. Analyze pharmacokinetic data obtained from preclinical and clinical pharmacokinetic studies, and fit appropriate pharmacokinetic and pharmacodynamic models to the data, as requested by investigators in this program. C. Perform genotyping studies on patient samples from clinical trials on Project 6 of this Program. D. Maintain computer databases of data from analyses performed in the Solid Tumor Pharmacology Core, and generate data retrievals and reports as required. E. Perform additional special laboratory procedures as required to support the projects included in this program.