Striatum/Amygdalostriatal Area

描述：(申请人摘要)腹侧(边缘相关)纹状体 调节动机行为，被认为是重要的解剖底物 精神错乱。杏仁核是一种突出的边缘结构，连接着复杂的感觉 刺激到他们的情感意义。腹侧纹状体可能是 Defined是基于中介情绪处理的结构的输入 杏仁核；与杏仁核相连的眶内侧前额叶区域，以及 背层多巴胺(DA)神经元。腹侧纹状体‘壳’是一种独特的 从这些结构接收受限输入的次区域，并且是 其特征是1.相对较低的Calbindin-DK28(CABP)染色，2.多个 具有物质F的不同分布的细胞(‘界面’)岛， 脑啡肽、乙酰胆碱酯酶(AChE)、酪氨酸羟基酶(TH)和D1. 3.杏仁核传入神经元和细胞之间的精确重叠区域 与特定发射器相关的星团，4.紧密重叠的区域 杏仁核和皮质传入之间。 我们假设尾侧腹侧纹状体和邻近的杏仁纹状体 区域(Astr)是腹侧边缘纹状体的一个特殊部分。 根据类似的标准，对颞叶输入进行分析。颞叶起调节作用 听觉和视觉处理，与杏仁核相互连接，是一种 精神分裂症的异常部位。我们的初步数据显示，比如 腹侧纹状体、尾侧纹状体/Astr区：1.接受 调节情绪的大脑结构的传入：杏仁核，特定区域 与杏仁核相连的皮质，以及多巴胺神经元。2.接收来自 DA神经元“背侧层”的尾部成分3.有一个CABP缺乏的区域， 和多个蜂窝岛与不同分布的 F物质、脑啡肽、AChE、TH和D1mRNA，与在 壳。 这些研究的第一个目标是确定尾侧腹侧 纹状体/ASTR区是腹侧纹状体的一部分， 细胞结构和组织化学特征。我们的第二个目标是研究 杏仁核向含有物质的细胞团投射的假说 P和DL受体在纹状体尾侧/ASTR区的表达，因此 处于激活这些递质/受体特定通路的位置。我们的 第三个目标是确定杏仁核和颞叶皮质的输入 汇聚在尾侧纹状体/Astr区。这些研究的结果 将提供一个解剖学框架来理解情感 重要的听觉和视觉信息在纹状体中被处理。

DESCRIPTION: (Applicant's abstract) The ventral ('limbic-related) striatum mediates motivated behavior, and is considered an important anatomic Substrate of psychosis. The amygdala, a prominent limbic structure, links complex sensory stimuli to their emotional significance. One way the ventral striatum can be defined is based on inputs from structuresthat mediate emotional processing the amygdala; orbitomedial prefrontal regions linked to the amygdala, and the dorsal tier dopamine (DA) neurons. The ventral striatal 'shell' is a unique subregion that receives restricted inputs from these structures, and is charactenzed by 1. Relatively low calbindin-Dk28 (CaBP) staining, 2. Multiple cellular ('interface') islands with differential distributions of substance F, enkephalin, acetyicholinesterase (AchE), tyrosine hydroxylase (TH), and D1 mRNA, 3. Regions of precise overlap between amygdaloid afferents and cell clusters associated with specific transmitters, 4. Regions of tight overlap between amygdaloid and cortical afferents. We hypothesize that the caudoventral striatum and adjacent amygdalostriatal area (Astr) is a special part of the ventral 'limbic' striatum that is devoted to temporal lobe inputs, based on similar criteria. The temporal lobes mediate auditory and visual processing, are interconnected with the amygdala, and are a site of abnormalities in schizophrenia. Our preliminary data suggest that, like the ventral striatum, the caudoventral striatum/Astr area: 1. Receives afferents from brain structures mediating emotion: amygdala, specific regions of cortex linked to the amygdala, and the DA neurons. 2. Receives input from a caudal component of the 'dorsal tier' of DA neurons 3. Has a CaBP-poor region, and multiple cellular islands associated with varying distributions of substance F, enkephalin, AchE, TH, and D1 mRNA, similar to that found in the shell. The first goal of these studies is to determine whether the caudoventral striatum/Astr area is part of the ventral striatum based on connectional, cytoarchitectural, and histochemical features. Our second aim is to examine the hypothesis that the amygdala projects to cellular clusters containing substance P and Dl receptor mRNA in the caudoventral striatal/Astr area, and is therfore in a position to activate these transmitter/receptor specific pathways. Our third aim is to determine whether amygdaloid and temporal cortical inputs converge in the caudoventral striatum/Astr area. The results of these studies will provide an anatomic framework for understanding how emotionally significant auditory and visual information is processed in the striatum.