SLEEP APNEA--DETERMINANTS AND CONSEQUENCES

该提案有两个关键目标：1）：加强Badr博士作为独立研究者的职业发展; 2）提供受保护的时间，使Badr博士能够指导初级教师和研究员，长期目标是达到睡眠研究的关键质量。 该建议涵盖了当前和未来研究的两个领域：1。使用纤维光学成像研究UA通畅性的决定因素，特别强调REM睡眠。 2)探讨睡眠时呼吸不稳定的机制以及呼吸驱动与UA通畅性之间的相互作用。 目前的研究关注的是在反复扰动后稳定呼吸的长期易化机制。 拟定的研究将在自然睡眠期间的人类中进行，受试者将涵盖UA稳定的范围，包括正常人、打鼾者和睡眠呼吸暂停患者。

This proposal has two key objectives: 1) : To enhance career development for Dr. Badr as an independent investigator; 2) To provide protected time to allow Dr. Badr to mentor junior faculty and research fellows with the long term goal of reaching a critical mass of investigators in sleep research. This proposal covers two areas of current and future research: 1. To investigate the determinants of UA patency using fiberoptic imaging with special emphasis on REM sleep. 2) To investigate mechanisms of breathing instability during sleep and the interaction between ventilatory drive and UA patency. The current studies are concerned with long-term facilitation mechanisms which stabilize respiration after repeated perturbation. The proposed studies will be conducted in humans during natural sleep, subjects will span the spectrum at UA stability including normals, snorers and sleep apnea patients.