STRUCTURE DETERMINATION OF DNA EXCISION REPAIR ENZYME UVRA

一氧化氮是一种小的、活性的、可扩散的、生物的 信使和细胞毒剂，参与多种不同的 生理过程包括神经传递，血液凝结， 血压与肿瘤细胞和细胞内的保护 寄生虫。我们希望确定iNOS的结构，这是一种可以 含有独特的辅因子组合，催化新的单加氧酶 化学，涉及人类生物学的许多方面，并将 直接解决有关此功能的特定问题 包括为什么这种酶不会立即被它的 产品一氧化氮。

Nitric oxide is a small, reactive, diffusible, biological messenger and cytotoxic agent that is involved in a wide variety of physiological processes including neurotransmission, blood clotting, blood pressure and protection against tumor cells and intracellular parasites. We wish to determine the structure of iNOS, an enzyme that contains a unique cofactor assembly, catalyzes novel monooxygenase chemistry and is involved in many aspects of human biology, and will directly address specific questions regarding the function of this enzyme including why this enzyme is not immediately inhibited by its product nitric oxide.