STRUCTURAL STUDIES OF ACETATE KINASE

神经营养因子神经生长因子、脑源性神经营养因子 生长因子)和NT3(神经营养因子-3)介导的存活和 神经元通过其特定的非共价结合而分化 作为与细胞表面受体TrkA、TrkB和TrkC的同源二聚体， 属于同一家族的跨膜酪氨酸激酶。而当 NGF的晶体结构和a的胞外结构域存在 跨膜酪氨酸激酶(EGF受体)，知之甚少 关于这些集合之间的特殊性的结构基础 分子。这种知识是开发一种分子所必需的 神经系统退行性疾病的治疗方法。

The neurotrophins NGF (nerve growth factor), BDNF (brain-derived growth factor), and NT3 (neurotrophin-3) mediate the survival and differentiation of neurons via their specific noncovalent association as homodimers with cell surface receptors, trkA, trkB, and trkC, members of the same family of transmembrane tyrosine kinases. While crystal structures exist for NGF and an extracellular domain of a transmembrane tyrosine kinases (EGF receptor), little is known regarding the structural basis of specificity between these sets of molecules. Such knowledge is needed to develop a molecular therapeutic approach to degenerative diseases of the nervous system.