STRUCTURE OF COMPLEX BETWEEN TFIIIA & ITS 31 BP DNA SITE
STRUCTURE OF COMPLEX BETWEEN TFIIIA & ITS 31 BP DNA SITE
批准号:
6658592
负责人:
STEPHEN COPLAN HARRISON
金额:
$14.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-03-01 至 2003-02-28
中文摘要
多个锌指图案最初在非洲爪哇中被发现
转录因子IIIA(TFIIIA)。每个主题都是一个独立的
折叠蛋白结构域。九个串联的锌指出现在
TFIIIA,允许蛋白质与5S的广泛区域结合
RNA基因启动子。有一个相对“标准”的对接大多数
代表的手指插入DNA的主要沟槽,但
GLI结构显示,一个手指基本上没有DNA接触。
因此,具有3个以上手指的蛋白质可能具有高度的分歧
对接模式。本研究的目的是检验一个蒸馏器
更长的复杂性。
英文摘要
Multiple zinc finger motifs were originally discovered in Xenopus
transcription factor IIIA (TFIIIA). Each motif is an independently
folded protein domain. Nine tandem zinc fingers are present in
TFIIIA, allowing the protein to bind to an extensive region of the 5S
RNA gene promoter. There is a relatively "standard" docking of most
of the fingers represented in set into the major groove of DNA, but
the GLI structure shows one finger with essentially no DNA contacts.
Thus, proteins with more than 3 fingers may have highly divergent
docking modes. The goal of the present study is to examine a still
longer complex.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Structural biology of antibody:antigen complexes
-
批准号:8516984
-
项目类别:
-
资助金额:$37.29万
-
财政年份:2013
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Administrative Core
-
批准号:8516985
-
项目类别:
-
资助金额:$4.99万
-
财政年份:2013
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Structural biology of antibody:antigen complexes
-
批准号:8377204
-
项目类别:
-
资助金额:$25.45万
-
财政年份:2012
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Administrative Core
-
批准号:8377206
-
项目类别:
-
资助金额:$12.87万
-
财政年份:2012
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Project #1: Harrison
-
批准号:8462406
-
项目类别:
-
资助金额:$75.9万
-
财政年份:2012
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Core A: Administrative Core
-
批准号:10549603
-
项目类别:
-
资助金额:$7.08万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Discovery of small molecules to block fusion and entry of dengue and other env vi
-
批准号:8233434
-
项目类别:
-
资助金额:$31.92万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Structural biology of antibody:antigen complexes
-
批准号:8329266
-
项目类别:
-
资助金额:$25.75万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Project 4: Structural Biology of Influenza Antibody-Antigen Interactions
-
批准号:10549614
-
项目类别:
-
资助金额:$31.86万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Structure-function analysis of infection- and vaccine-induced B-cell repertoires
-
批准号:10549602
-
项目类别:
-
资助金额:$299.48万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Structure-function analysis of infection- and vaccine-induced B-cell repertoires
-
批准号:8516979
-
项目类别:
-
资助金额:$210.02万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Structure-function analysis of infection- and vaccine-induced B-cell repertoires
-
批准号:8303235
-
项目类别:
-
资助金额:$216.85万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
STRUCTURE OF MCM21 PROTEIN COMPLEX
-
批准号:8361723
-
项目类别:
-
资助金额:$1.1万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Structure-function analysis of infection- and vaccine-induced B-cell repertoires
-
批准号:9751703
-
项目类别:
-
资助金额:$262.08万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Structural Biology Core
-
批准号:8294664
-
项目类别:
-
资助金额:$103.6万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Structure-function analysis of infection- and vaccine-induced B-cell repertoires
-
批准号:8153253
-
项目类别:
-
资助金额:$220.29万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Structural biology and immunogen design
-
批准号:10229504
-
项目类别:
-
资助金额:$119.86万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Administrative Core
-
批准号:8329275
-
项目类别:
-
资助金额:$13.46万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Administrative Core A
-
批准号:10229499
-
项目类别:
-
资助金额:$10.62万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
Structure-function analysis of infection- and vaccine-induced B-cell repertoires
-
批准号:8720673
-
项目类别:
-
资助金额:$226.89万
-
财政年份:2011
-
负责人:STEPHEN COPLAN HARRISON
-
依托单位:
海外基金