CRYSTAL STRUCTURE OF HUMAN APOLIPOPROTEIN I

载脂蛋白A-I（apoA-I）是肝硬化的主要蛋白质成分， 在人体血液中发现的高密度脂蛋白（HDL）颗粒。 高 HDL水平，尤其是HDL的apoA-I含量， 与动脉粥样硬化风险降低相关，因此降低了 冠心病的风险。 ApoA-I还在细胞凋亡中发挥关键作用。 通过激活血浆酶组装HDL颗粒 卵磷脂-胆固醇酰基转移酶（LCAT）。 我们需要同步加速器 辐射来收集高分辨率的数据，因为这种结构具有 对apoA-I如何与HDL中的脂质结合具有深远的意义。

Apolipoprotein A-I (apoA-I) is the major protein component of high-density lipoprotein (HDL) particles found in human blood. High levels of HDL, and especially the apoA-I content of HDL, strongly correlate with a reduced risk of atherosclerosis, and hence a reduced risk of coronary artery disease. ApoA-I also plays a key role in the assembly of HDL particles by activating the plasma enzyme lecithin-cholesterol acyl transferase (LCAT). We need synchrotron radiation to collect high-resolution data as this structure has profound implications for how apoA-I binds to lipid in HDL.