CRYO-ROP HEADQUARTERS--PHASE IV

尽管冷冻治疗严重ROP已被证明在保护出生体重低于1251克的早产儿童视力方面显著有效，但有理由预计，多年来患有严重ROP的眼睛，无论治疗或未治疗，并发症都会增加。随着随访持续到学龄期，ROP受损的眼睛正在发展为新的或更广泛的视网膜脱离、白内障和带状角膜病变-所有这些情况不仅会恶化已经很差的视力，还会导致眼睛疼痛。随着这些儿童进入青春期，特别令人担忧的是，视力保留的眼睛将遭受晚期视网膜脱离或进行性光感受器衰竭，从而导致视力下降。这项正在进行的研究提供了机会，以确定冷冻治疗在儿童早期积累的好处是否会在青春期持续下去。为了确定这一点，将在15岁时进行检查，其中将包括对患有严重ROP的治疗和未治疗眼的结构和功能进行客观掩蔽评估。治疗和未治疗的眼睛之间的发病率将进行比较，许多后遗症和并发症，如晚期视网膜脱离，黄斑变性，视力下降。

Although cryotherapy as a treatment for severe ROP has been proven significantly effective in preserving vision among children who were born prematurely with birth weights below 1251 grams, there is reason to expect mounting complications over the years in eyes that had severe ROP, whether treated or untreated. As follow-up has continued into school age, eyes damaged by ROP are developing new or more extensive retinal detachment, cataracts, and band keratopathy-all conditions that not only can worsen already poor vision, but also can cause ocular pain. As these children enter adolescence, there is particular concern that eyes with preserved vision will sustain late retinal detachments or progressive photoreceptor failure, and consequent decline of visual acuity. This ongoing study affords the opportunity to ascertain whether the benefits of cryotherapy that accrued during early childhood will be sustained in adolescence. To determine this, an examination will be conducted at age 15 that will include objective masked assessment of both structure and function in treated and untreated eyes with severe ROP. An incidence comparison will be made between treated and untreated eyes for many sequelae and complications, such as late retinal detachment, macular degeneration, and vision failure.