Concordance Rates of Mobiluncus Among Sexual Partners

描述(申请人提供)：细菌性阴道病(BV)是全世界最流行的阴道炎形式，与早产和感染性病/艾滋病毒等并发症有关。BV的病因仍不清楚，尽管它的流行病学反映了一种性传播疾病。除Mobiluncus spp外，大多数与BV相关的微生物都是通过培养技术在健康阴道中少量检测到的。这似乎与BV有很强的关联。然而，这种微生物是一种高度挑剔的厌氧菌，培养可能低估了阴道样本中的真实流行率。我们建议使用聚合酶链式反应(PCR)来检验性伴侣中移行线虫物种的符合率。我们的假设是，柯蒂斯移动虫在BV的发病机制中起重要作用，性伴侣之间的高符合率将被发现，暗示着性传播。

DESCRIPTION (provided by applicant): Bacterial vaginosis (BV) is the most prevalent form of vaginitis worldwide and has been linked to complications such as preterm birth and STD/HIV acquisition. The etiology of BV remains unknown although its epidemiology mirrors that of a sexually transmitted disease. Most of the microorganisms associated with BV are detected by culture techniques in the healthy vagina in small numbers with the exception of Mobiluncus spp. which seems to be strongly associated with BV. However, this organism is a highly fastidious anaerobe and culture may underestimate the true prevalence in vaginal samples. We propose to use polymerase chain techniques (PCR) to examine the concordance rates of Mobiluncus species among sexual partners. Our hypothesis is that Mobiluncus curtisii is important in the pathogenesis of BV and high concordance rates among sexual partners will be found suggesting sexual transmission.