CELL MEDIATED CYTOTOXICITY

描述(改编自《调查者摘要》)：长距离 本项目的目的是探讨其起源、分化、 和NK细胞的功能。工作假说，源于他们的 研究和其他人的研究表明，NK细胞代表着相对 同质离散细胞型，具有多种防御和调节功能 活性，包括但不限于细胞介导的细胞毒性和 NK细胞在体内的有效性和特异性取决于 与体液因子和其他细胞因子相互作用的复杂网络 类型。尽管最近在这方面取得了很大进展， 自然杀伤细胞的特性及其抑制和刺激作用 受体及其产生细胞因子的能力，确切地说 自然杀伤细胞在先天适应交界处的生理作用 免疫，以及它们被激活的机制 病态侮辱仍在等待更好的理解。Trin Chieri博士 假设NK细胞除了在先天免疫中的直接作用外 抵抗力，在塑造获得性免疫类型中发挥作用 应答以及在调节性NK细胞中重要的细胞因子 活性，特别是干扰素-α和白介素12，以及产生 它们构成了免疫调节相互作用的重要支柱。 在先天抵抗力和后天免疫力之间。为了 进一步了解这种免疫调节机制，他建议 研究：1)增殖、细胞因子的产生和分化 自然杀伤细胞。2)信号分子C1.7-Ag的性质和功能 NK细胞上的转导受体与CD8t活化的标志 细胞。3)干扰素-α产生细胞与细胞因子的关系 树突状细胞与干扰素-α的生理相关性 树突状细胞与NK细胞和T细胞的相互作用

DESCRIPTION (Adapted from Investigator's Abstract): The long rang objective of this project is to investigate the origin, differentiation, and function of NK cells. The working hypothesis, derived from their research and that of others, is that NK cells represent a relatively homogenous discrete cell type, with various defensive and regulatory activities, including but not limited to cell-mediated cytotoxicity and that the effectiveness and specificity of NK cells in vivo depend on a complex network of interactions with humoral factors and other cellular types. Although much progress has been made recently on the characterization of NK cells, their inhibitory and stimulatory receptors, and their ability to produce cytokines, the exact physiological roles of NK cells at the interface of innate and adaptive immunity, and the mechanisms of their activation in response to pathological insults still await a better understanding. Dr. Trinchieri hypothesized that NK cells, in addition to their direct role in innate resistance, play an role in shaping the type of adaptive immune responses and that the cytokines important in regulatory NK cell activity, particularly IFN-alpha and IL-12, and the cell types producing them constitute an important backbone in the immunoregulatory cross-talk between the innate resistance and acquired immunity. In order to understand further this immuno-regulatory mechanism, he proposes to investigate: 1) Proliferation, cytokine production and differentiation of NK cells. 2) Characterization and function of C1.7 Ag, a signal transducing receptor on NK cells and a marker of activation of CD8 t cells. 3) The relationship between IFN-alpha producing cells and dendritic cells and the physiological relevance of IFN-alpha in the interaction of dendritic cells with NK cells and T cells.