CMV infections in AIDS patients on clinical protocols

内容摘要：（1）项目目标： - 由于CMV被认为是艾滋病患者的主要机会性感染之一，因此监测参加各种临床试验的患者的血液、尿液和组织标本中是否存在CMV非常重要。 - 确定抗HIV三联疗法引起的CD4计数升高是否能有效控制CMV视网膜炎。 (2)临床方案的目的： 确定在没有特异性抗CMV治疗的情况下，有效抗病毒治疗后CD4+计数升高的HIV感染个体的免疫功能是否能有效控制CMV视网膜炎。 (3)迄今取得的成果： 在停止抗CMV治疗1年后，没有患者发生CMV视网膜炎复发或发生眼外CMV疾病。 正在编写的出版物：HIV感染和巨细胞病毒视网膜炎患者特异性抗巨细胞病毒治疗的成功终止：一项纵向干预试验的结果

Summary: (1) Goals of Project: - Since CMV is recognized as one of the leading opportunistic infections in AIDS patients, it is important to monitor blood, urine, and tissue specimens from patients enrolled in various clinical trials for the presence of CMV. - Determine whether elevated CD4 counts resulting from triple therapy against HIV are effective in controling CMV retinitis. (2) Purpose of Clinical Protocols: To determine whether immune function in HIV-infected individuals with elevated CD4+ counts on potent antiviral therapy is effective in controlling CMV retinitis without specific anti- CMV therapy. (3) Results to date: No patient has had reactivation of CMV retinitis or has developed extraocular CMV disease after 1 year following discontinuation of anti-CMV therapy. Publication in preparation: Successful discontinuation of specific anti-cytomegalovirus therapy in persons with HIV infection and cytomegalovirus retinitis: Results of a longitudinal intervention trial.