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Investigation of inhibition of current supplies of Immun

Investigation of inhibition of current supplies of Immun
免疫电流供应抑制的研究
批准号:
6682271
负责人:
M C ANDERSON
金额:
$0.0万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
摘要:LST目前正在评估几种Vero细胞测定方法,以替代目前的动物试验;一种检测方法是测定免疫球蛋白(IG)对白喉毒素的中和活性。经过一些试验修改,许多IG被CBER参考天花疫苗检测了它们抑制Vero细胞感染的能力,该疫苗已被证明在几种细胞类型的传统斑块试验中具有活性。虽然仍在开发中,但初步结果表明,目前许多IG在该试验中具有不同的保护Vero细胞的能力。
英文摘要
Summary: LST is currently evaluating several Vero Cell Assays as replacements for current animal tests; one assay involves determining the neutralizing activity of Immune Globulins(IG) on Diphtheria Toxin. With some assay modifications, lots of IG were examined for their ability to inhibit infection of Vero Cells by the current CBER Reference Smallpox vaccine, which has been shown to be active in a traditional plaque assay with several cell types. While still under development, preliminary results have indicated that current lots of IG have varying ability to protect Vero Cells in this assay.
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RUNNING POSSIBLE COLLABORATORY EXPERIMENTS
  • 批准号:
    7598762
  • 项目类别:
  • 资助金额:
    $0.12万
  • 财政年份:
    2007
  • 负责人:
    M C ANDERSON
  • 依托单位:
DEVELOPMENT OF AN IMMUNOLOGICALLY BASED COCKROACH ANTIGEN DETECTION SYSTEM
  • 批准号:
    5200870
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    M C ANDERSON
  • 依托单位:
    --
STABILITY OF TETANUS AND DIPHTHERIA TOXINS USING IMMUNOELECTROPHORESIS METHODS
  • 批准号:
    5200869
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    M C ANDERSON
  • 依托单位:
    --
ISOELECTRIC FOCUSING PROCEDURES FOR ALLERGENIC EXTRACTS
  • 批准号:
    3804575
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    M C ANDERSON
  • 依托单位:
    --
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