Enzyme-mediated modification of peptide hydrogels to tailor them for drug delivery and tissue engineering

这个生物技术项目是与定制的多肽合成公司Pepceuticals合作进行的，将涉及合成小肽，已知这些小肽可以自组装成能够包裹药物或支持哺乳动物细胞生长的水凝胶，并对这些多肽的一部分进行修饰，以提供额外的锚点、化学队列和其他功能，从而显著增强水凝胶的功能。这些修饰将使用酶介导的过程或各种生物结合方法进行。所生产的支架将在再生医学和伤口愈合方面找到未来的用途。

This biotechnology project which is conducted in collaboration with the custom peptide synthesis company Pepceuticals, will involve the synthesis of small peptides, known to self-assemble into hydrogels capable of either encapsulating drugs or supporting mammalian cell growth and modifying a proportion of these peptides to provide additional anchor points, chemical queues and other functionality that will significantly enhance the capabilities of the hydrogel. These modifications will be conducted using either enzyme-mediated processes or a variety of bioconjugation methods. The scaffolds produced will find future uses in regenerative medicine and wound healing.