CORE--BIOSTATISTICS AND RECRUITMENT

生物统计和招募核心（正式名称为人类评估和生物统计核心）将继续作为睡眠和睡眠呼吸暂停神经生物学研究特别中心的一部分发挥不可或缺的作用。核心的具体目标（职能）是：1）满足两个人类研究项目和两个动物项目的生物统计需求，为这些项目带来的数据分析挑战提供创新解决方案（所有项目）; 2）向人力资源项目提供集中的统计方案编制和数据管理资源（Weaver和Kuna的项目; 3）应用现有的方法，并为发展与定义与稳态睡眠调节的遗传控制相关的表型特征相关的最佳统计方法做出实质性贡献（Weaver和Kuna的项目; 4）支持人类和动物的数据库管理基础设施开发（所有项目）; 5）促进所有SCOR研究人员正确使用统计原则和实验设计（所有项目）;以及6）提供能够招募呼吸暂停患者的招募基础设施（Weaver的项目）和双胞胎（Kuna的项目），后者将通过与现有双胞胎队列（PennTwins，E. Coccaro）。核心C（生物统计和招募核心）由经验丰富的生物统计学家、统计程序员、数据库经理和临床招募人员组成。核心C工作人员之间以及核心C工作人员与SCOR调查员之间的合作历史悠久。核心C的核心负责人自1988年成立以来一直担任SCOR生物统计学家，自1990年以来一直担任核心负责人。他与SCOR研究人员有着广泛的合作记录，并在睡眠领域进行了原创性研究。核心负责人（高级生物统计学家）将由一名生物统计学助理协助，该助理的工作重点是为动物研究提供生物统计学支持，并在应用适用于这些项目拟定实验设计的混合效应统计模型方面具有丰富经验。Core C还包括一名与Core有长期联系的高级SAS TM统计程序员，他专门开发用于实施复杂统计模型的分析系统，这些模型利用来自多个来源的数据，一名经验丰富的数据库管理员/具有Access数据库开发专业知识的统计程序员，以及一名数据员。此外，核心负责人将由一名经验丰富的高级临床研究招募人员协助，该招募人员将指导人体研究招募职能，与PennTwins队列进行联络， 将由更多的征聘工作人员协助。与SCOR研究人员合作的经验，科学兴趣和悠久的历史使生物统计和招募核心能够为项目提供最先进的统计，数据库管理和人类研究招募支持，同时促进必要的统计方法的进步，以解决项目的具体目标。

The Biostatistical and Recruitment Core (formally, Human Assessment and Biostatistics Core) will continue to play an integral role as part of the Special Center of Research in Neurobiology of Sleep and Sleep Apnea. The Core's specific aims (functions) are: 1) to meet the biostatistical needs of the two human study projects and two animal projects providing innovative solutions to data analysis challenges arising from these projects (all projects); 2) to provide centralized statistical programming and data management resources to the human projects (Projects by Weaver and Kuna and; 3) to apply existing methods and to make substantial contributions to the development of optimal statistical methods related to defining phenotypic characteristics associated with genetic control of homeostatic sleep regulation (Projects by Weaver and Kuna; 4) to support database management infrastructure development for the human and animal (all projects); 5) to promote the sound use of statistical principles and experimental design by all SCOR investigators (all projects); and 6) to provide the recruitment infrastructure enabling recruitment of apnea patients (Project by Weaver) and twins (Project by Kuna), the latter to be facilitated through a partnership with an existing twin cohort (PennTwins, E. Coccaro). Core C (Biostatistical and Recruitment Core) is comprised of a very experienced team of biostatisticians, statistical programmers, database managers, and clinical recruitment personnel. There exists a long history of collaboration among Core C staff and between Core C staff and SCOR investigators. The Core Leader of Core C has been SCOR biostatistician since its inception in 1988 and Core Leader since 1990. He has an extensive record of collaboration with SCOR investigators as well as original research in the field of sleep. The Core Leader (Senior Biostatistician) will be assisted by an Associate Biostatistician whose focus will be on providing biostatistical support to the animal studies and who is experienced in applying the mixed effects statistical models appropriate for the experimental designs proposed for these projects. Core C also includes a senior SAS TM statistical programmer with a longtime association with the Core who specializes in the development of analysis systems for implementation of complex statistical models that utilize data from multiple sources, an experienced database manager/statistical programmer with expertise in Access database development, and a data clerk. In addition, the Core Leader will be assisted by an experienced senior clinical study recruiter who will direct the human studies recruitment function, provide liaison with the PennTwins Cohort, and who will be assisted by additional recruitment staff. The experience, scientific interest, and long history of collaboration with SCOR investigators make the Biostatistical and Recruitment Core well-positioned to provide state-of-the-art statistical, database management, and human studies recruitment support to the projects while contributing to the advancement of statistical methods necessary to address the specific aims of the projects.