Particle engineering approaches to control the interaction of medicinal aerosols with the lung environment following inhalation

翻译后摘要：气雾剂疗法被广泛用于治疗呼吸系统和全身性疾病。因此，重要的研究已经进入活性药物成分和递送装置如何影响颗粒沉积和患者结果。然而，在呼吸系统中，对特定的物理化学气溶胶特性的水蒸气相互作用的依赖性的研究仍然有限。因此，它们对肺环境内的吸湿生长、溶解和凝聚的影响常常被忽视。该项目的重点是通过干粉吸入器输送固体药物颗粒，并回顾了一些颗粒特性，这些特性可能是呼吸系统湿度下气溶胶动力学的基础。此外，在响应中，提出了一种新的方法来生产单分散模型粒子具有独特的特性和性能，使用微流体结晶技术。模型颗粒的后续研究将允许确定微粒体性质（如尺寸、表面积和结晶度）对固体药物颗粒与人肺中水分相互作用的影响程度。在这样做的过程中，它将增强对呼吸系统中气溶胶动力学的基本原理的理解，并有助于优化气溶胶药物递送技术的潜力。

Abstract: Aerosol therapeutics are widely used in the treatment of respiratory and systemic disease. As such, significant research has gone into how the active pharmaceutical ingredient and delivery device affect particle deposition and patient outcomes. However, there remains limited research on the dependency of water vapour interactions, in the respiratory system, on specific, physicochemical aerosol properties. Consequently, their influence on hygroscopic growth, dissolution and agglomeration within the lung environment is often overlooked. This project focuses on the delivery of solid drug particles by dry powder inhalers and reviews some of the particle properties that may underpin aerosol dynamics in the humidity of the respiratory system. Furthermore, in response, a novel way to produce monodisperse model particles with distinct characteristics and properties using microfluidic crystallisation techniques is presented. The subsequent investigation of the model particles will allow for the determination of the extent of impact that micromeritic properties, such as size, surface area and crystallinity, have on the interaction of solid drug particles with moisture in the human lung. In doing so, it will enhance the understanding of the fundamental, underlying principles of aerosol dynamics in the respiratory system and contribute to the potential for optimisation of aerosol drug delivery techniques.