BLOOD AND MARROW TRANSPLANT CLINICAL RESEARCH NETWORK

描述(由申请人提供)： 这项拨款申请的目标是成为临床核心项目之一。 中心在拟议的血液和骨髓移植临床研究网络中。 弗雷德·哈钦森癌症研究中心有许多特色 (FECRC)骨髓移植计划使其成为有吸引力的候选人 包括在网络中。首先，我们保持了一个大而稳定的移植 几十年的计划，每年移植450到550名患者 在过去的一年里，取得了出色的临床效果。因此，我们可以访问相对 病人数量很多。第二，我们的群体包括大量的 研究人员将注意力集中在移植的一般主题上。这群人是 得到了7个P0和23个R0的支持，去年发表了142篇关于 主题。因此，我们的收录将有助于确保可能的研究来源 未来在移植网络中的测试。第三，我们的节目深度 致力于临床合作研究。例如，去年451人中有231人 在西雅图移植的患者(51%)进入了多机构 审判。最后，FHCRC提供了一个出色的环境，在其中 进行所描述的各种研究，使用最先进的临床和 实验室设施。建议的血液和骨髓移植临床 研究网络具有促进研究的潜力 移植结果的实质性改善。包括 弗雷德·哈钦森癌症研究中心在这个网络上应该会帮助它实现 这个目标。

DESCRIPTION (provided by applicant): The objective of this grant application is to become one of the core clinical centers in the proposed Blood and Marrow Transplant Clinical Research Network. There are a number of features of the Fred Hutchinson Cancer Research Center (FECRC) Marrow Transplant Program that make it an attractive candidate for inclusion in the Network. First, we have maintained a large, stable transplant program for several decades transplanting between 450 and 550 patients per year with excellent clinical outcomes. Thus, we have access to a relatively large number of patients. Second, our group includes a large number of investigators focused on the general topic of transplantation. This group is supported by seven P0ls and 23 R0ls, and last year published 142 papers on the topic. Thus, our inclusion will help assure a source of possible studies for future testing in the Transplant Network. Third, our program is deeply committed to cooperative clinical research. For example, last year 231 of 451 patients transplanted in Seattle (51%) were entered onto multi-institutional trials. Finally, the FHCRC provides an outstanding environment in which to conduct the sorts of studies described, with state-of-the-art clinical and laboratory facilities. The proposed Blood and Marrow Transplant Clinical Research Network has the potential to facilitate studies leading to substantial improvements in the outcome of transplantation. Inclusion of the Fred Hutchinson Cancer Research Center in this network should help it achieve this goal.