Research Program: Hematologic Malignancies

研究项目：血液系统恶性肿瘤

• 批准号: 9001930
• 负责人: FREDERICK APPELBAUM
• 金额: $ 3.47万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9001930
• 关键词: American; Area; Breast; Cancer Center Support Grant; Cancer Etiology; Caring; Cessation of life; Clinical Services; Clinical Trials; Colon; Diagnosis; Disease; Disease Progression; Funding; Goals; Grant; Hematologic Neoplasms; Institution; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Methods; Molecular Abnormality; Monitor; Myeloproliferative disease; Pancreas; Paper; Patients; Peer Review; Principal Investigator; Publishing; Research; Science; Transplantation; Work; base; hematopoietic cell transplantation; improved; inter-institutional; member; novel; novel strategies; novel therapeutics; programs; screening; treatment group

Hematologic Malignancies Program The goal of the Program in Hematologic Malignancies is to develop a better understanding and improved treatments for this group of diseases. Four areas of focus predominate: (1) Developing a deeper understanding of the biologic basis of hematologic malignancies; (2) Using this understanding to develop better non- transplant therapies; (3) Discovering novel methods to overcome the current limitations of hematopoietic cell transplantation; and (4) Using these discoveries to improve the actual practice of hematopoietic cell transplantation. The Hematologic Malignancies program currently has 75 members from 11 departments and 3 institutions. Seventy-three Members (97%) have peer-reviewed funding or are the Principal Investigator on a clinical trial. The Hematologic Malignancies program currently has $24.3M in grant funding (direct dollars) of which $16.9M is peer-reviewed and $6.9M (40%) is from NCI. The Program published a total of 1218 papers in the previous grant period. 27% were intra-programmatic, 35% were inter-programmatic and 19% were inter- institutional. In 2012, 148,040 Americans were diagnosed with a hematologic malignancy, resulting in 54,380 deaths, making these malignancies collectively the second leading cause of cancer death after lung cancer (160,340), and exceeding in aggregate the deaths from colon (51,690), breast (39,920) pancreas (37,390), and prostate cancer (28,170). Previous work from our program has improved our understanding of this group of diseases, particularly the myeloid malignancies, leading to new approaches to screening for genetic abnormalities, improved monitoring of disease progression and novel therapeutics. Results from our studies have also led to a better understanding of the science behind problems of hematopoietic cell transplantation and provided methods to overcome some of these problems leading to improved cure rates. Members of this program also oversee a very busy clinical service, caring for 802 new patients in 2013 alone, of which 466 (58%) were treated on clinical trials.

恶性血液病项目