Supplement to RR15577-Mentoring Immunology in Oklahoma:

描述(由申请人提供)： 这项建议是对资助的Cobre P20RR15577《俄克拉荷马州的免疫学辅导》的补充。俄克拉荷马医学研究基金会(OMRF)寻求资金，为科布雷调查人员翻新3000英尺2的空间，用于新的程序性工作区和生物遏制研究区。《保护和使用实验动物指南》建议为实验程序提供专门的实验室或与动物设施相连的空间。目前的程序空间不到200英尺2，已经过时了。由于日程冲突或空间限制，科布雷研究人员的工作经常被推迟，许多人被迫将动物从设施中移出进行实验程序，然后将它们送回，在某些情况下，项目必须取消或在其他机构进行。OMRF已将此确定为一项迫切需要，并已将这类空间纳入其长期资本项目规划。所要求的翻修不仅将纠正所述的不足之处，而且将为科布雷调查人员和监察员办公室带来新的和急需的专门知识领域。一个新的程序区，结合了冷冻微型机和激光解剖显微镜的空间，将极大地增强Cobre成像和微阵列核心，并增加新的和令人兴奋的研究能力。增加目前俄克拉荷马州没有的生物遏制空间，将在很大程度上加强Cobre赠款的所有项目；信号核心、微注射核心加上对来自俄克拉荷马大学和俄克拉荷马州立大学的Cobre研究人员的合作具有巨大的区域重要性。OMRF已承诺投入大量资源改善资本，以便在PHS资助的研究补助金方面更具竞争力，但需要继续提供研究基础设施，以便继续取得有意义的进展。

DESCRIPTION (provided by applicant): This proposal is a supplement to the funded COBRE P20 RR15577 "Mentoring Immunology in Oklahoma". The Oklahoma Medical Research Foundation (OMRF) seeks funding for the renovation of 3000 ft 2 of space for new procedural work areas and biocontainment research areas for the COBRE investigators. The Guide for the Care and Use of Laboratory Animals recommends that specialized laboratories or space contiguous with animal facilities be provided for experimental procedures. The current procedural space consists of less than 200 ft 2 and is antiquated. COBRE investigators often have their work delayed due to scheduling Conflicts or space limitations, many are forced to remove the animals from the facility for experimental procedures then return them and in some instances projects must be cancelled or conducted at other institutions. OMRF has identified this as a critical need and has included this type of space into its long range capital project planning. The requested renovation would not only correct the stated deficiency but would bring new and much needed areas of expertise to the COBRE investigators and OMRF. A novel procedural area that incorporates space for a cryomicrotome and a laser dissection microscope would greatly enhance the COBRE imaging and microarray cores and add new and exciting research capability. The addition of biocontainment space, currently not available in Oklahoma, would enhance all the projects of the COBRE grant in a major way; the signaling core, the microinjection core plus be of tremendous regional importance to the collaboration of COBRE investigators from the University of Oklahoma and Oklahoma State University. OMRF has committed significant resources to capital improvement in order to be more competitive for PHS funded research grants but needs to continue to provide research infrastructure in order to continue to make meaningful progress.