FETAL AND NEONATAL CEREBRAL PHYSIOLOGY

描述(申请人提供)：在美国，每年12%的活产婴儿(47万名婴儿)发生早产，是婴儿死亡和发病的主要原因，每年与超过20亿美元的医疗保健费用有关。这些死亡率和长期发病率很大程度上是由围产期脑血流和新陈代谢障碍引起的。近年来，尽管存活早产儿的临床治疗策略逐渐减少了脑血管发病率，但成人脑血管病理的临床治疗进展缓慢，并影响了对新生儿脑损伤的研究。同样，最近在了解发育中胎儿心血管、免疫学和内分泌动态平衡的基本机制方面的进展也很慢，在执业新生儿医生中也是如此，特别是在涉及高危早产儿的情况下。这些学科间有限的想法传递率是广泛的专业化和狭窄的重点的自然结果，继而扩大了许多新生儿医生的临床责任。因此，拟议的会议旨在将主要对新生儿脑血管病理生理学感兴趣的研究人员聚集在一起，科学家们主要专注于成人脑血管调节的研究，而科学家的专长则集中在发育中的胎儿的心血管、免疫和内分泌调节方面。为此，组织了围产期脑缺氧缺血学会、脑血流和代谢学会以及胎儿和新生儿生理学学会的联席会议。这一大型会议将包括1000多篇摘要和演讲，其中包括一次研讨会(白质发育中的缺氧-缺血损伤)和三次主旨讲座：围产期脑发育：历史概述；胎儿心血管发育；以及胎儿内分泌学的新概念。这次会议的背景是加拿大的卡尔加里，这将提供一个美丽和放松的氛围，充满了主要国际大都市中心的所有便利设施和交通便利。组织者热切期待这次独特的联席会议将提供一个前所未有的机会，就胎儿脑血管调节和病理生理学进行跨学科的思想交流。

DESCRIPTION (provided by applicant): Pre-term delivery occurs in 12% of live births (470,000 infants) in the United States each year, is a major cause of infant mortality and morbidity, and is associated with health care costs of more than $2 billion annually. Much of this mortality and long-term morbidity results from perinatal disturbances in cerebral perfusion and metabolism. Whereas strategies for clinical management of surviving pre-term infants have gradually reduced cerebrovascular morbidity in recent years, major improvements in clinical management of adult cerebrovascular pathologies have been slow to reach and influence studies of the neonatal cerebral injury. Similarly, recent advances in understanding of fundamental mechanisms of cardiovascular, immunological, and endocrine homeostasis in the developing fetus have also been slow to find an audience among practicing neonatologists, particularly where at-risk pre-term infants are concerned. These limited rates of idea transfer between disciplines are natural consequences of extensive specialization and narrowed focus secondary to expanding clinical responsibilities for many neonatologists. Accordingly, the proposed conference has been designed to bring together investigators interested mainly in neonatal cerebrovascular pathophysiology, with scientists focusing mainly on studies of adult cerebrovascular regulation, and scientists whose expertise centers on cardiovascular, immunological, and endocrine regulation in the developing fetus. To that end, a joint meeting of the Perinatal Cerebral Hypoxia-lschemia Society, the Society for Cerebral Blood Flow and Metabolism, and the Fetal and Neonatal Physiology Society has been organized. This large meeting will involve more than 1000 abstracts and presentations, among which support is requested for one symposium (Hypoxic-lschemic Damage in Developing White Matter) and three keynote lectures: Perinatal Brain Development: A Historical Overview; Fetal Cardiovascular Development; and New Concepts in Fetal Endocrinology. The setting for this conference is in Calgary, Canada, which will provide a beautiful and relaxing atmosphere replete with all the amenities and easy accessibility of a major cosmopolitan center. The organizers enthusiastically anticipate that this unique joint meeting will offer an unprecedented opportunity for an inter-disciplinary exchange of ideas related to fetal cerebrovascular regulation and pathophysiology.