4th International Symposium on Hormonal Carcinogenesis

描述(由申请人提供)：荷尔蒙癌症发生国际研讨会(ISHC)是致力于研究激素和其他生长调节剂在激素相关癌症的起因、促进和发展中的作用的美国和外国研究人员的主要国际论坛。其中一些肿瘤，特别是乳腺癌、前列腺癌、卵巢癌和子宫内膜癌，是美国和发达国家女性和男性中最常见的癌症，仍然是一个主要的公共卫生问题。这些研讨会独特地吸引了来自不同学科的坚定的流行病学家、基础科学家和临床医生，如细胞和分子生物学、内分泌学、药理学、生殖毒理学、病理学、妇科和泌尿外科肿瘤学以及流行病学。受邀的演讲者从事与激素相关的癌症和其他研究领域的前沿，如细胞周期、染色体结构和功能、上皮-间质相互作用、基因组学和蛋白质组学，这些领域可能直接导致该领域的新发展。 ISHC将于2003年6月21日至25日与西班牙巴伦西亚的巴伦西亚大学癌症中心联合举行。这一专题讨论会的独特之处在于，在每届会议中将不同学科结合在一起，这些学科涉及一个单一的重点议题。这种方法将培养一种翻译精神。本次研讨会的七场会议包括：1.乳腺癌I，孕激素作用；2.乳腺癌II--基因组不稳定的机制；3.早期原位病变：乳腺癌和前列腺癌；4.促进和预防荷尔蒙癌症；5.前列腺癌--雄激素/雌激素作用：6.前列腺癌II--雄激素受体：依赖和抵抗；7.子宫内膜/卵巢/结肠癌。该计划还将包括一位全体研讨会演讲者，三位最先进的演讲者，以及两个海报会议(流行病学/临床和分子生物学/新陈代谢)。初级调查人员将被鼓励参加海报会议。由于这些研讨会涉及荷尔蒙致癌和激素依赖性癌症领域的最新进展，会议记录将以书籍的形式出版，以便像过去一样在世界范围内传播。

DESCRIPTION (provided by applicant): The International Symposia on Hormonal Carcinogenesis (ISHC) is the premier international forum for both USA and foreign investigators dedicated to study the role of hormones and other growth regulators in the causation, promotion, and progression of hormone-associated cancers. Some of these neoplasms, specifically, breast, prostate, ovarian, and endometrial, represent the most prevalent cancers occurring in females and males in the USA and developed countries, and continue to be a major public health concern. These Symposia uniquely attract committed epidemiologists, basic scientists, and clinicians of diverse disciplines, such as cell and molecular biology, endocrinology, pharmacology, reproductive toxicology, pathology, gynecologic and urologic oncology, and epidemiology. Invited speakers are engaged in the cutting edge of hormone-related cancer and other areas of research, such as cell cycle, chromosome structure and function, epithelial-stroma interactions, genomics, and proteomics, which may have a direct bearing in leading to new developments in the field. The ISHC will be held in association with the University of Valencia Cancer Center in Valencia, Spain, June 21-25, 2003. Unique to this particular Symposium will be the integration of various disciplines within each session which bear on a single focused topic. This approach will foster a translational spirit. The seven sessions of this symposia include: 1. Breast Cancer I, Progesterone Action; 2. Breast Cancer II - Mechanisms of Genomic Instability; 3. Early In-Situ Lesions: Breast and Prostate Cancer; 4. Promotion and Prevention of Hormonal Cancers; 5. Prostate I - Androgen/Estrogen Action: 6. Prostate II - Androgen Receptor: Dependence and Resistance; and 7. Endometrium/Ovarian/ Colon Cancers. The program will also include a Plenary Symposium speaker, three State of the Art speakers, and two Poster Sessions (Epidemiology/Clinical and Molecular Biology/Metabolism). Junior investigators will be encouraged to participate in the Poster Sessions. Since these Symposia address the most recent advances in the field of hormonal carcinogenesis and hormone-dependent cancers, the proceedings will be published in book form for world-wide dissemination, as it has been in the past.