Meetings on Advances in Nanostructural Genomics

描述：（由申请人提供）此申请为每年在缅因州巴尔港的杰克逊实验室举行的“纳米结构基因组学进展”会议提供部分支持，为期5年。这些会议的主要目标是吸引来自多学科的研究人员的兴趣和参与，这些研究人员必须承担解决该领域复杂的生物学问题。正如完整的基因列表将促进人类遗传疾病的诊断和治疗一样，对基因组结构和功能的深入了解将为理解发育和疾病的分子基础奠定坚实的基础。生物物理、化学和纳米科学方法研究核基因组的结构和活性最近得到了发展，并在这一领域具有相当大的前景。在基因组组织和功能的选择基本问题将回顾和讨论的背景下，新的观点和方法跨几个学科。推进这些概念并解决如此复杂的生物学问题需要物理学家、化学家和材料科学家与细胞、发育和基因组生物学家合作的协调网络。在这方面，许多目前用于研究大规模核结构的方法学方法也可能对中尺度，特别是纳米尺度上的基因组结构研究非常有用。

DESCRIPTION: (provided by applicant) This application is for 5 years of partial support for the meeting "Advances in Nanostructural Genomics" held at annually at The Jackson Laboratory in Bar Harbor, Maine. The primary objective of these meetings is to recruit the interest and participation of researchers from the multiple disciplines that must be brought to bear on solving complex biological problems in this area. Just as the complete gene list will advance the diagnosis and treatment of human genetic disorders, insight into genome structure and function will constitute a solid foundation for understanding the molecular basis of development and disease. Biophysical, chemical and nanoscience approaches to the study of nuclear genome structure and activity have been recently developing and hold considerable promise in this area. A selection of fundamental problems in genome organization and function will be reviewed and discussed in the context of new perspectives and approaches across several disciplines. Advancing these concepts and solving such complex biological problems will require coordinated networks of physicists, chemists and materials scientists collaborating with cell, developmental and genome biologists. In this regard, many of the methodological approaches currently used to approach large-scale nuclear architecture may be highly useful also to study genome structure at the mesoscale and especially at the nanoscale level. This meeting will provide a forum for an interdisciplinary discussion on the short and long-term research goals for correlating genome architecture with biological function. A focused approach connecting biology, nanotechnology, and mathematical modeling is required to make rapid progress in this fundamental and important research area. We anticipate that worldwide leading scientists in the disciplines needed for a comprehensive approach to functional genomics will participate in the discussions. This meeting, first held in October of 2001, has become the springboard for the newly formed "Genome Architecture Consortium", a multidisciplinary core of investigators which has, and will continue to, produce reports identifying the research needs, opportunities, and challenges in determining and understanding the structure of the genome and its relationship to biological function. The 2003 meeting will be held on October 16-19.