Nanostructured, Liquid Crystalline Dental Restoratives

描述：本申请的目标是合成一种纳米结构热固性树脂，用作牙科修复剂。纳米结构热固性材料将具有优于传统复合材料的性能。骨骼和牙齿是纳米结构复合材料的例子，我们的目标是利用和模仿这些材料中发现的纳米级控制。将合成纳米级的积木，并用于形成具有优异机械性能的纳米结构热固性。对积木结构的简单修改将影响热固性的块体性质。分子构建块可以作为开发一系列功能材料的平台。基于多面体倍半硅氧烷(POSS)的液晶有机-无机杂化材料将被用作构建块。POSS既包含有机成分，也包含无机成分，因此可以配制出可控的复合材料结构，而不会出现固有的混合问题。液晶相将赋予液晶构建块纳米级的秩序。为了保持纳米级的有序，液晶POSS将通过添加甲基丙烯酸酯基团使其可见光固化。用可见光照射将形成一种热固性物质，它将保持液晶相的纳米级有序。用X射线衍射仪和透射电子显微镜对热固性材料进行了表征，以确定其纳米结构。将进行弯曲强度、压缩强度、收缩和磨损等临床性能的常规评估。这一应用代表了牙科修复体设计的一种新方法。

DESCRIPTION: The goal of this application is to synthesize a nanostructured thermoset for use as a Dental restorative. A nanostructured thermoset will have superior properties to conventional composite materials. Bone and teeth are examples of nanostructured composites and our goal is to take advantage and mimic the nanoscale control found in these materials. Nanoscale building blocks will be synthesized and used to form nanostructured thermosets with superior mechanical properties. Simple modifications to the structure of the building blocks will affect the bulk properties of the thermosets. The molecular building blocks can act as a platform to develop a broad range of functional materials. Liquid crystalline organic-inorganic hybrids based on polyhedral silsesquioxane (POSS) will be used as the building blocks. POSS contains both organic and inorganic components so controlled composite structures can be formulated without the inherent problems of mixing. The liquid crystalline phase will impart nanoscale order to the liquid crystalline building blocks. To retain the nanoscale order, the liquid crystalline POSS will be made visible light curable with the addition of methacrylate groups. Irradiation with visible light will form a thermoset that will retain the nanoscale order of the liquid crystalline phase. The thermosets will be evaluated by X-ray diffraction and TEM to confirm their nanostructure. Conventional evaluations for clinical performance such as flexural strength, compressive strength, shrinkage and wear will be performed. This application represents a new methodology in the design of dental restoratives.