Exercise & Sleep: A clinical Trial in Menopausal Women

描述（由申请人提供）：在美国约5000万绝经后妇女中，估计有80%的人抱怨睡眠模式中断，其特征是睡眠不足。 一些研究表明，雌激素的相对缺乏会干扰最佳睡眠，而外源性雌激素替代品可以改善睡眠。 然而，据报道，不到15%的绝经后妇女使用雌激素替代疗法。 越来越多的证据表明，运动可以改善绝经后妇女自我报告的睡眠质量。 这项研究的长期目标是开发一种运动处方，以改善绝经后妇女的睡眠。 本研究应用的具体目标是确定中等强度的家庭锻炼计划对客观睡眠参数、自我报告的睡眠质量和白天嗜睡的影响。 中心假设是，有规律的锻炼计划将改善睡眠结构和睡眠连续性模式，主观睡眠质量，以及雌激素缺乏的绝经后妇女白天嗜睡。 采用实验性、重复测量、随机治疗对照组设计，将40名雌激素缺乏、久坐且有睡眠维持障碍的绝经后妇女随机分配到两个条件之一：运动组或对照组。 运动将以家庭为基础，中等强度的步行，每周5次，每次持续30分钟。 将在基线和16周运动或非运动期后测量睡眠结构、睡眠连续性、睡眠质量和日间嗜睡。 还将收集关于雌二醇和昼夜核心体温节律的潜在介导变量的数据。

DESCRIPTION (provided by applicant): An estimated 80 percent of the approximately 50 million postmenopausal women in the United States have complaints of disrupted sleep patterns characterized by sleep loss. Several studies show that a relative lack of estrogen interferes with optimal sleep and exogenous estrogen replacement improves sleep maintenance. However, it has been reported that less than 15 percent of postmenopausal women use estrogen replacement therapy. A growing body of evidence demonstrates that exercise improves self-reported sleep quality in postmenopausal women. The long-range goal of this research is to develop an exercise prescription that will improve the sleep of postmenopausal women. The specific objective of this research application is to determine the effects of a moderate intensity, home-based exercises program on objective sleep parameters, self-reported sleep quality, and daytime sleepiness. The central hypothesis is that a regular exercise program will improve the sleep architecture and sleep continuity patterns, subjective sleep quality, and daytime sleepiness in estrogen-deficient postmenopausal women. Employing an experimental, repeated measures, randomized treatment control group design, forty postmenopausal women who are estrogen deficient, sedentary, and have a sleep maintenance disorder will be randomly assigned to one of two conditions; an exercise group or a control group. The exercise will be home-based, moderate intensity walking with a frequency of 5 times per week and a duration of 30 minutes per session. Measurements of sleep architecture, sleep continuity, sleep quality and daytime sleepiness will be obtained at baseline and after the 16-week exercise or non-exercise period. Data on potential mediating variables of estradiol and circadian core body temperature rhythm will also be collected.