Understanding Fully Continuous Tablet Manufacturing Processes Using Experimental and Modelling Tools

在本项目中，将使用连续粉末至片剂生产线GEA consigma-25。该生产线由一系列以连续方式连接的单元操作（进料、双螺杆制粒、流化床干燥、研磨、混合和压片）组成，以连续生产高达25 kg/hr的片剂。虽然在制药工业中的单一单元操作是相当好的理解，但它们以连续方式的利用并没有得到很好的记录。

In this project a continuous powder to tablet line GEA consigma-25 will be utilised. This line consists of a series of unit operations (feeding, twin screw granulation, fluidised bed drying, milling, blending and tabletting) connected in a continuous fashion in order to produce continuously up to 25kg/hr of tablets. Although the singular unit operation in the pharmaceutical industry are fairly well understood their utilisation in a continuous fashion is not as well documented.