EarLab: A Virtual Hearing Laboratory

描述(申请人提供)：EarLab项目的远景目标 是创造现实的、基于网络的模型，能够预测人类的听觉 对各种声音刺激或环境侮辱的反应。 应用范围从预测声学过度刺激如何导致 听力障碍解释人类如何在复杂的环境中发挥作用 声学环境。为了实现我们的目标，我们将综合和整合 关于哺乳动物听力的现有信息，并创造出有助于 来自不同研究的研究人员之间的有效互动 纪律。这些模型将提高我们利用所获得知识的能力 并将其应用于人类。在建设和建设的过程中 集成EarLab模型和工具，将确定数据差距，从而 需要通过未来的动物和/或人体研究来填补。神经科学 目标是：1)建立一个完整的耳蜗功能模型；2) 建立噪声性听力损失模型；3)建立综合模型 声源本地化。信息学的目标是：1)创建 基于Web的听觉建模环境的计算基础设施，2) 创建一个智能虚拟实验室，使快速 重新配置模拟和互换模型模块，以及 辅助仿真设计的参考信息，以及3)开发用户 用于模型配置和数据可视化的界面。

DESCRIPTION (provided by applicant): The long-range goal of the EarLab project is to create realistic, web-based models capable of predicting human auditory responses to a wide range of acoustic stimuli or environmental insults. Applications range from predicting how acoustic over-stimulation leads to hearing impairment to explaining how humans are able to function in complex acoustic environments. To achieve our goal we will synthesize and integrate existing information on mammalian hearing and create tools that will facilitate effective interaction between investigators from different research disciplines. The models will improve our ability to take the knowledge obtained from animal models and apply it to humans. In the process of constructing and integrating the EarLab models and tools, data gaps will be identified that will need to be filled by future animal and/or human studies. The neuroscience objectives are to: 1) develop an integrated model of cochlear function, 2) develop a model of noise-induced hearing loss, and 3) develop integrated models of sound-source localization. The informatics goals are: 1) to create the computational infrastructure for a web-based auditory modeling environment, 2) to create an intelligent virtual laboratory that will allow rapid reconfiguration of simulations and interchange of model modules, as well as reference information to aid simulation design, and 3) to develop a user interface for model configuration and data visualization.