BIOACTIVE COMPOSITE COATINGS FOR IMPLANTS

描述（改编自研究者摘要）：植入物材料 这是一个极端的挑战，因为他们必须满足许多冲突， 要求.没有一种材料可以满足所有这些要求，通常一种材料 涂上另一层。涂层代表了进一步的材料挑战，因为 它们需要与基材结合，同时保持其主要功能， 特性.这是真实的，在骨的替换中，金属合金， 维持骨骼负荷所需的结构特性， 羟基磷灰石类材料，以改善骨整合和生物固定， 剩下的骨头。申请人的策略是涂覆Ti及其合金 用的是亨奇发明的生物活性玻璃可靠 已经产生了在模拟体内形成磷灰石的粘附涂层 液这种眼镜已经被证明可以促进骨肉瘤细胞的粘附， 这对于骨整合是有希望的。该研究将优化 钛表面生物活性涂层和钴铬表面类似涂层的性能 合金.功能梯度和复合材料将用于生产 涂层具有定制的性能，如生物活性和生物吸收性。 含玻璃和玻璃的功能梯度材料（FGM）涂层 将制备羟基磷灰石（HA）和磷酸三钙（TCP）。涂层 将通过SEM、TEM和XRD进行分析，以确定界面处的反应 与金属接触，也在涂层内。FGM的底层将是 选择粘附性能并通过俄歇和XPS分析。的顶部 FGM将通过在模拟体液（SBF）中老化进行研究， 通过测定HA形成的溶解度和程度。组织培养 测试将用于确定最佳的表面粗糙度和体内研究 将用于通过组织形态学检查骨-植入物界面， 组织学、SEM和拔出试验。建议开展研究， 对涂层结构稳定性和粘附性的机械理解 金属子结构因此，涂层的机械性能 并确定了它们的界面， 建立关系以指导临床医生选择材料。 断裂力学模型和技术将应用于评估 强度/缺陷交互作用、断裂韧性和应力腐蚀裂纹 增长由于涂层将用于身体，几乎所有这些技术将 扩展到包括循环疲劳条件。

DESCRIPTION (Adapted from the Investigator's Abstract): Implant materials represent an extreme challenge since they must satisfy many conflicting requirements. No one material can meet them all, and often one material is coated with another. The coatings represent further material challenges in that they need to bond to the substrate while maintaining their primary functional properties. This is true in the replacement of bone where metal alloys, with the structural properties needed to sustain skeletal loading, are coated with hydroxyapatite-like materials to improve osseointegration and biofixation with the remaining bone. The applicant's strategy has been to coat Ti and its alloys with bioactive glasses modified from those developed by Hench. Reliably adherent coatings have been produced that form apatite in a simulated body fluid. The glasses have been shown to promote adherence of osteosarcoma cells, which is promising for osseointegration. The proposed research will optimize the properties of bioactive coatings on Ti and similar coatings on Co-Cr alloys. Functionally graded and composite materials will be used to produce coatings with tailored properties such as bioactivity and bioresorptivity. Functionally graded materials (FGM) coatings containing glasses and hydroxyapatite (HA) and tricalcium phosphate (TCP) will be prepared. Coatings will be analyzed by SEM, TEM, and XRD to identify reactions at the interface with metal and also within the coating. The bottom layer of the FGM will be selected for adherence properties and be analyzed by Auger and XPS. The top of the FGM will be studied through aging in simulated body fluid (SBF), followed by a determination of the solubility and extent of HA formation. Tissue culture tests will be used to determine optimal surface roughness and in vivo studies will be used to examine the bone-implant interface through histomorphology, histology, SEM, and pullout tests. Studies are proposed to develop a clear mechanistic understanding of coating structural stability and adherence to metal substructures. Consequently, the mechanical properties of the coatings and their interfaces will be determined and microstructure-property relationships developed to guide clinicians in their choice of materials. Fracture mechanics models and techniques will be applied to the evaluation of strength/flaw interactions, fracture toughness, and stress corrosion crack growth. As coatings will be used in the body, nearly all these techniques will be expanded to involve cyclic fatigue conditions.