HYDROXYAPATITE COATINGS ON TI-BASED IMPLANTS

钛基植入物上的羟基磷灰石涂层

• 批准号: 2654449
• 负责人: ANTONI P TOMSIA
• 金额: $ 34.86万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2000-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2654449
• 关键词: X ray crystallography; adhesions; biomaterial development /preparation; biomaterial evaluation; bone fracture; facial bones; glass; hydroxyapatites; mechanical stress; molecular film; oral facial restoration material; oxidation reduction reaction; scanning electron microscopy; tensile strength; titanium

Surgical and dental implants represent one of the fastest growing sectors in the health care industry. As many as 40 biomaterials are used for the 50 prosthetic devices used in medical and dental surgery. The proposed research program seeks to develop strongly adherent bioactive hydroxapatite (A) coatings on Titanium alloy implants. The program aims to develop a basic understanding of adherence (bonding), internal stresses and interfacial fracture resistance for HA coatings on Ti alloys. The program has three main goals: 1) to develop strongly adherent bioactive coatings on Ti alloys, 2) to elucidate a detailed understanding of the coating/Ti adherence, and 3) to provide fundamental understanding of the mechanical degradation of protective commercial and experimental HA coating layers through the measurement of internal stresses and interfacial fracture resistance for the HA/Ti coating systems. Several glasses in the system P2O5-MgO-CaO-SiO2-Na2-O-K2O system will be prepared. These glasses are adapted based on bioactive glass originally developed by Hench. Coatings will be made to study wetting and prepare specimens for interfacial reaction studies. Coated specimens will be analyzed by SEM, microprobe and thin film x-ray diffraction (TF-XRD) to identify the redox reactions that take place at the interface and with the glasses, and analysis of the interface itself by Auger and XPS with slow sputtering of surfaced parallel to the interface. Stability of the glasses will be determined in simulated body fluid (SBF) experiments. Glass surfaces after immersion experiments in SBF will be analyzed by SEM, TF-XRD, AAS, ICP and FTIS in order to determine the extent of HA formation on glass surfaces. Internal stresses and thermal expansion mismatch stresses will be analyzed by refined methods for performing in situ deflection measurements for determination of the residual stresses and stress gradients within the coating system. The objective will be to develop methods with sufficient precision to characterize both stresses at the interface and thermal stresses and to provide an adequate description of the driving forces for coating delamination and cracking. The fracture resistance of the coatings and the coating Ti/interface will be studied at room temperature by fracture mechanics testing and tensile testing of coated specimens. Indentation tests will also be used to measure the resistance to crack propagation (i.e., "toughness") of the interface, and thereby provide a quantitative measure of the bond strength.

外科和牙科植入物是增长最快的 在医疗保健行业。 多达40种生物材料 用于医疗和牙科手术中使用的50种修复装置。 拟议的研究计划旨在开发强烈粘附 钛合金植入物上的生物活性羟基磷灰石（A）涂层。 的 该计划旨在培养对坚持的基本理解 HA的键合、内应力和界面抗断裂性能 钛合金涂层。 该计划有三个主要目标：1） 在钛合金上开发强粘附性生物活性涂层，2） 阐明对涂层/钛粘附性的详细理解，以及3） 提供对机械降解的基本理解， 保护性商业和实验HA涂层， 内应力和界面断裂抗力的测量 用于HA/Ti涂层系统。 P_2O_5-MgO-CaO-SiO_2-Na_2-O-K_2 O系统中的几种玻璃 系统将准备。 这些眼镜是根据生物活性 玻璃最初由亨奇开发。 涂层将被研究 润湿并制备用于界面反应研究的样品。 涂覆 样品将通过SEM、微探针和薄膜X射线进行分析 衍射（TF-XRD），以确定发生的氧化还原反应， 界面和眼镜，以及界面本身的分析， 俄歇和XPS与表面平行的缓慢溅射 接口. 将在模拟体液中测定眼镜的稳定性 (SBF)实验 玻璃表面浸泡实验后， 采用SEM、TF-XRD、AAS、ICP和FTIS等方法对SBF进行分析， 以确定HA在玻璃表面上形成的程度。 内应力和热膨胀失配应力将被 通过改进的方法进行现场偏转分析 测定残余应力和应力的测量 涂层系统内的梯度。 目标是发展 具有足够精度的方法，以表征 界面和热应力，并提供充分的描述 涂层分层和开裂的驱动力。 的 涂层和涂层Ti/界面的抗断裂性将 研究在室温下通过断裂力学测试和拉伸 涂层试样的测试。 压痕测试还将用于 测量抗裂纹扩展性（即，“韧性”）的 界面，并由此提供结合的定量测量 实力