Agents of International Health & Bioterrorism Concern

描述（由申请人提供）：阿拉巴马大学伯明翰分校提议开展一项博士前和博士后联合培训资助，重点研究生物防御利益的代理人，包括新兴的和国际利益的关键生物。我们机构在微生物学、传染病流行病学、临床研究和产品开发转化工作方面的优势已经在这一领域产生了大量的研究。因此，我们认为，现在是提供一笔大规模培训拨款的最佳时机，以激发新的专业知识，以应对后9/11、后炭疽时代我们面临的大量工作。项目负责人、执行委员会、核心导师均具有较强的培训和相关研究能力；我们是经验丰富的导师，将受训者与资助和可资助的研究联系起来。我们的计划包括为少数族裔，特别是非洲裔美国人，特别招聘学员。通过类似的培训资助，我们提供在研究伦理、资助写作、手稿准备和IRB问题方面经过严格审查的课程或模块。我们的具体目标是：1。提供博士前培训，使学生获得流行病学、环境卫生工程、环境卫生科学或国际卫生方面的研究学位，促进在转化研究方面的研究事业。2. 通过研究方法、公共卫生、生物防御/新发传染病、生物技术和疫苗开发等方面的跨学科培训，使博士后受训者能够在国际卫生/生物防御领域开展独立的研究事业。研究和培训重点是(1)临床和分子流行病学；(2)应用微生物学；和/或(3)生物防御/传染病快速反应、预防和控制的运筹学研究。在对NIAID目前支持的NRSA培训经费进行全面审查后，我们选择了这些主题，注意到它们非常以基础科学为导向，很少支持转化研究，而转化研究是当前公共卫生服务领导层明确强调的最高优先事项。我们的学员将以这些应用目标为目标，他们的研究将集中在这个转化研究领域。

DESCRIPTION (provided by applicant): The University of Alabama at Birmingham proposes to conduct a combined pre-doctoral and post-doctoral training grant that focuses on agents of biodefense interest, including key organisms of emerging and international interest. The strengths of our institution in microbiology, infectious disease epidemiology, clinical research, and translational work towards product development have generated considerable research in this arena. Thus, we believe the timing is perfect for a major training grant to stimulate new expertise needed for the mountain of work that faces us in the post 9/11, post-anthrax era. The PI, Executive Committee, and core mentors are all highly qualified in both training and relevant research; we are experienced mentors, linking trainees to funded and fundable research. Our plans include special recruitment efforts for minority trainees, particularly African-Americans. With analogous training grants, we offer well vetted courses or modules in research ethics, grant-writing, manuscript preparation, and IRB issues. Our specific aims are to:1. Provide pre-doctoral training leading to a research degree in epidemiology, environmental health engineering, environmental health sciences, or international health, facilitating research careers in the conduct of translational research. 2. Enable post-doctoral trainees to initiate independent research careers in international health/biodefense through cross-discipline training in research methods, public health, biodefense/emerging infectious diseases, and biotechnology and vaccine development. The research and training foci are (1) clinical and molecular epidemiology; (2) applied microbiology; and/or (3) operations research into biodefense/infectious disease rapid response, prevention, and control. We have chosen these themes after a comprehensive review of NRSA training grants supported currently by the NIAID, noting that they are very basic-science oriented with very few in support of the translational research that is so explicitly highlighted as highest priority by current Public Health Service leadership. Our trainees will be recruited with these applied goals in mind and their research will be focused in this translational research area.