INTERDICISPLINARY PROGRAM IN BACTERIAL PATHOGENESIS

描述（由申请人提供）：尽管在公共卫生和医学治疗方面取得了进展，但传染病仍然是世界范围内发病率和死亡率的主要原因，并且由于诸如新兴病原体、艾滋病或其他免疫损害状况以及抗微生物剂耐药性等因素，即使在发达国家也造成了相当大的经济和社会损失。培训能够阐明微生物发病机制的新科学家对于制定预防、诊断和治疗传染病的改进策略至关重要。这个新的申请支持细菌致病机制的培训计划中心周围的一个既定的和高度互动的跨学科研究社区在华盛顿大学。来自基础和临床科学不同背景的六名博士前和六名博士后学员将由来自微生物学，病理生物学和基因组科学部门的15名科学家以及成人和儿科传染病部门的教师指导。将从几个优秀的申请人中征聘候选人，并将积极从任职人数不足的少数群体中寻找合格的受训人员。培训教师在NIH支持的细菌致病机理研究方面有着杰出的记录，在博士前和博士后科学家的指导方面取得了成功，并获得了优秀的科学资源和基础设施。研究项目包括重要的革兰氏阳性，革兰氏阴性，分枝杆菌，衣原体和螺旋体病原体，包括关注宿主-病原体相互作用的生化，遗传，分子，细胞生物学和免疫学方面。学员将受益于全面的课程，包括分子细菌学，免疫学和科学伦理学的核心课程，双周工作进展会议，发病机理杂志俱乐部，临床微生物学回合，以及广泛的研讨会和传染病临床会议。该计划的总体目标是让科学家准备使用跨学科和假设驱动的方法来获得对细菌发病机制的新见解，从而为预防和管理传染病提供新的方法。

DESCRIPTION (provided by applicant): Despite advances in public health and medical therapeutics, infectious diseases continue to represent the leading cause of morbidity and mortality worldwide and extract a considerable financial and societal toll even in developed countries due to factors such as emerging pathogens, AIDS or other immunocompromising conditions, and antimicrobial resistance. The training of new scientists who can elucidate basic mechanisms of microbial pathogenesis will be critical for the formulation of improved strategies to prevent, diagnose and treat infectious diseases. This new application for support of a Training Program in Bacterial Pathogenesis centers around an established and highly interactive interdisciplinary research community at the University of Washington. Six pre- and six post-doctoral trainees from diverse backgrounds in basic and clinical sciences will be mentored by a faculty of 15 scientists from the Departments of Microbiology, Pathobiology, and Genome Sciences, as well as the Divisions of Adult and Pediatric Infectious Diseases. Candidates will be recruited from several outstanding applicant pools, and qualified trainees from underrepresented minority groups will be actively sought. The training faculty has a distinguished track record in NIH-supported bacterial pathogenesis research, documented success in the mentoring of predoctoral and postdoctoral scientists, and access to excellent scientific resources and infrastructure. Research projects encompass important Gram-positive, Gram-negative, mycobacterial, chlamydial, and spirochetal pathogens, including attention to biochemical, genetic, molecular, cell biological, and immunological aspects of host-pathogen interactions. Trainees will benefit from a comprehensive curriculum that includes core courses in molecular bacteriology, immunology, and scientific ethics, a bi-weekly work-in-progress meeting, pathogenesis journal club, clinical microbiology rounds, and a wide range of seminars and infectious diseases clinical conferences. The overall goal of this program is to prepare scientists to use an interdisciplinary and hypothesis-driven approach to obtain new insights into mechanisms of bacterial pathogenesis that can lead to novel approaches for the prevention and management of infectious diseases.