Development of the prevention program adapting 3DS from the systemic bacterial infection for the children under immunity control before Hemopoietic stem cell transplantation

免疫控制儿童造血干细胞移植前全身细菌感染3DS预防方案的制定

• 批准号: 21792073
• 负责人: KADOMOTO Noriko
• 金额: $ 2.58万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792073/
• 关键词: 3DS; 感染予防; 免疫抑制; 造血幹細胞移植

We developed a new oral prevention program adapting 3DS(Dental Drug Delivery System). When we applied the new program for the children under immunity control before Hemopoietic stem cell transplantation, the number of bacteria in the mouth decreased and it maintained the low value for 3 months. And the program made less inflammation of oral mucous membrane than usual. Therefore, the new 3DS prevention program can decrease the risk of the children' s systemic bacterial infection, and it can improve their Quality of Life.

我们开发了一种新的口腔预防方案，采用3DS（牙科药物输送系统）。对造血干细胞移植前免疫控制的患儿应用新方案后，口腔细菌数明显下降，并维持3个月。口腔黏膜炎症反应较平时明显减轻。因此，新的3DS预防方案可以降低儿童全身性细菌感染的风险，提高儿童的生活质量。