Non-invasive blood glucose monitor

描述(由申请人提供)： 该计划将开发一种新的基于近红外激光的分光光度计，适用于经皮血糖测定。使用传统光谱仪和热光源的非侵入性血糖监测仪存在信噪比不足的问题，无法稳定地预测血糖浓度。我们计划开发和测试的基于激光的系统有望显示出更高的血糖信噪比测量结果，因此具有更高的灵敏度和特异性。这些反过来将为生理和表型变量提供更好的解释。与其他方法相比，建议的技术具有显著的优势，即基于一种固有的可小型化、高能效和机械稳定的技术，这将允许开发紧凑型健壮系统。这项技术有望从根本上改善糖尿病患者监测血糖的频率。它将对糖尿病引起的公共卫生问题产生重大影响。 该项目的第一阶段将通过临床全血样本的体外测量来确定拟议方法的可行性。在这个项目的第二阶段，将建造一个基于第一阶段设计的系统的手持式活体监测器的原型，并将进行临床试验。 仅在美国，糖尿病血糖自我监测设备市场的总价值就达到12亿美元。 这项技术可以为许多行业带来好处。除了在医疗设备中用于血糖测量和监测人体内的其他代谢物外，它还可以用于食品和制药行业，以及环境监测和工业安全。

DESCRIPTION (provided by applicant): The proposed program will develop a novel near-infrared laser based spectrophotometer suitable for transcutaneous determination of blood glucose. Non-invasive blood glucose monitors that utilize conventional spectrometers and thermal light sources suffer from insufficient signal-to-noise ratio for the stable prediction of glucose concentration. The laser-based system we propose to develop and test is expected to exhibit superior signal-to-noise measurements of glucose, and therefore better sensitivity and specificity. These in turn will provide a better account for physiological and phenotypic variables. The proposed technology has the significant advantage over other approaches of being based upon an inherently miniaturizable, power-efficient, and mechanically stable technology that will permit the development of a compact robust system. This technology promises to produce a fundamental improvement in the frequency with which diabetic patients monitor their blood glucose. It will have a major impact on the public health issues arising from diabetes. Phase I of this project will determine the feasibility of the proposed approach by in-vitro measurements of clinical samples of whole blood. During Phase II of this project a prototype of a hand-held in-vivo monitor based upon the system engineered in Phase I will be constructed, and clinical trials will be conducted. Total diabetes glucose self-monitoring devices market for the U.S. alone was valued at $1.2 billion. There are number of industries that this technology could provide benefits. Besides obvious applications in medical devices for glucose measurements, and monitoring other metabolites in human body, it can be used in food and pharmaceutical industries, as well as for environmental monitoring and industrial safety.