Establishing the Intrinsic Regenerative Capacity of the Adult Human Heart in Health and Disease and the use of Recombinant Cellular Growth Factors to Reverse Heart Failure in vitro

心力衰竭是澳大利亚发病率和死亡率的主要原因。我们希望通过证明人类心脏可以再生来改变这种黯淡的前景，从而挑战长期以来认为我们的心脏不能再生的教条。使用人类心脏样本，我们将测量这些细胞在心力衰竭中再生的内在能力，并将其与正常、健康衰老的情况进行比较。此外，我们将探索使用细胞外生长因子来刺激这些心肌细胞

Heart failure is a major cause of morbidity and mortality in Australia. We hope to change this bleak outlook by showing that the human heart can regenerate, thereby challenging the long-held dogma that our heart cannot regrow. Using human heart samples we will measure the intrinsic capability of these cells to regenerate in heart failure compared to what occurs in normal, healthy ageing. In addition, we will explore the use of extracellular growth factors to stimulate these heart muscle cells