Training/Cellular/Molecular Mechanisms/Tumor Rejection

描述（由申请人提供）：癌症问题的免疫学解决方案在于我们能够引发有效的、强效的免疫应答，具有终身记忆，针对与自身分子没有太大不同的抗原。肿瘤细胞对免疫细胞的不同且通常是免疫抑制作用使问题变得更加复杂。这一令人兴奋的研究领域继续为在免疫学最新范式方面训练有素的年轻科学家提供挑战和机会。匹兹堡大学医学院的免疫学系过去成功地培养了许多有才华的研究人员，他们已经在肿瘤免疫学领域产生了重大影响。在该补助金的第一个资助期内，招募了高度成就的学员，并支持他们进行与肿瘤免疫学相关的研究。我们建议继续招募最好的和最聪明的进入这一研究领域，通过继续我们的博士前和博士后培训计划在肿瘤排斥的细胞和分子机制。我们在免疫学研究生培训计划中培训博士前学生和博士后研究员，这是匹兹堡大学医学院生物医学科学跨学科培训计划的九个培训计划之一。该培训补助金支持的目标是为学生和研究员提供课程，研究项目，高素质的导师和财政资源，使他们能够：1。阐明肿瘤特异性免疫启动的基本机制; 2.定义抗肿瘤免疫应答中的效应器机制;以及3.了解建立抗肿瘤长期免疫记忆的要求。我们通过精心策划和组织的课程活动，结合促进项目教师和学员之间实质性沟通的项目活动，实现了这些目标。该计划还努力培养研究生和研究员在他们的职业的其他重要方面：1。在同行评审的手稿和国家和国际会议上及时报告研究结果; 2.向各种私人和政府资助机构撰写赠款建议书; 3.教授与其专业领域相关的课程。

DESCRIPTION (provided by applicant): Immunological solutions to cancer problem lie in our ability to elicit effective, potent immune responses, with life long memory, against antigens that are not much different then self molecules. The problem is compounded by different and often immunosuppressive effects on the immune cells by tumor cells. This exciting field of research continues to provide challenges and opportunities for young scientists well trained in the newest paradigms in immunology. The immunology faculty at the University of Pittsburgh School of Medicine have successfully trained many talented investigators in the past who have already made significant impact in the field of tumor immunology. In the first funding period of this grant, highly accomplished trainees were recruited and supported in their research related to tumor immunology. We propose to continue to recruit the best and the brightest into this area of research through the continuation of our predoctoral and postdoctoral training program in Cellular and Molecular Mechanisms of Tumor Rejection. We train predoctoral students and postdoctoral fellows within our Graduate Training Program in Immunology, one of nine training programs of the Interdisciplinary Training Program in Biomedical Sciences of the University of Pittsburgh School of Medicine. The goals supported by this training grant are to provide students and fellows with courses, research projects, highly qualified mentors and financial resources which will allow them to: 1. Elucidate the basic mechanisms of initiation of tumor-specific immunity; 2. Define the effector mechanisms in the anti-tumor immune response; and 3. Understand the requirements for establishment of long-term antitumor immune memory. We have been accomplishing these goals through well-planned and organized course activities, combined with program activities that promote substantive communication among the program faculty and trainees. The program also strives to train both graduate students and fellows in other important aspects of their profession: 1. Reporting in a timely fashion research results in peer reviewed manuscripts and at national and international meetings; 2. Writing grant proposals to various private and government funding agencies; 3. Teaching in courses related to their field of expertise.