RESEARCH TRAINING IN RENAL DISEASE

描述（由申请人提供）： 该补助金要求支持继续为致力于研究肾脏疾病的病因和治疗的医生科学家提供研究培训计划。肾脏疾病影响着超过1300万美国人。近30万人患有终末期肾病，这一数字每年增加7%，每年花费联邦政府超过120亿美元用于透析和移植支持。该计划将提供为期三年的研究培训支持，每年由遴选委员会选出三名医生。受训者将是肾脏病学或其他学科的医学博士/博士或博士，他们致力于从事肾脏相关研究的职业，并具有实现这一目标的必要技能。将作出广泛努力，招聘代表性不足的少数族裔。该计划将由威廉博士谁一直是过去19年的项目主任。它将由斯图尔特·尚克兰博士共同指导，他是一位活跃的肾脏学基础研究者。七名肾脏科医生将担任主要导师。肾脏病学项目的所有成员都有生产性的、联邦和非联邦资助的研究项目，研究肾脏疾病，包括急性和慢性免疫性肾小球疾病、糖尿病、高血压和急性肾衰竭，在基本的细胞和分子水平上。肾脏病学项目工作人员将担任受训人员的主要导师，这些受训人员将与这些人一起度过1-2年，然后开始与基础科学项目工作人员的14名成员之一进行为期1-2年的基础科学强化培训。基础科学项目的所有成员都有资金充足的基础科学研究项目，可能应用于肾脏疾病，与肾脏病学项目的工作人员建立了合作科学互动，并在研究奖学金培训方面拥有丰富的经验。因此，将根据每个受训者自己的兴趣领域和长期目标为他们量身定制个人研究培训计划。还将提供细胞和分子生物学以及研究完整性方面的教学培训。该计划是在几个不同的部门多学科的支持学员，并由三个突出和经验丰富的高级研究导师的咨询委员会监督。在该方案前10年支助的12人中，5人目前担任学术职务，4人有联邦资助的研究方案，5人仍在培训中，2人已进入实践。

DESCRIPTION (provided by applicant): This grant requests support to continue a research training program for physician-scientists committed to pursuing research into the causes and cures of kidney disease. Kidney disease affects over 13 million Americans. Almost 300,000 have end-stage renal disease, a figure which increases 7% each year and costs the federal government over 12 billion dollars annually for dialysis and transplantation support. This program will provide three years support for research training to three physicians each year selected by a selection committee. Trainees will be MDs/PhD's or PhD's from nephrology or other disciplines who are committed to pursuing a career in renal-related research and have the requisite skills to achieve this goal. Extensive efforts to recruit under-represented minorities will be made. The program will be directed by Dr. William Couser who has been the Program Director for the past 19 years. It will be co-directed by Dr. Stuart Shankland, an active basic investigator in nephrology. Seven physicians in nephrology will serve as primary mentors. All members of the nephrology program staff have productive, federal and non-federal-funded research programs studying renal diseases including acute and chronic immune glomerular diseases, diabetes, hypertension, and acute renal failure at a basic cellular and molecular level. Nephrology program staff will serve as primary mentors for trainees who will spend 1-2 years with these individuals before beginning a 1-2 year period of intensive training in basic science with one of the 14 members of the basic science program staff. All members of the basic science program staff have well-funded research programs in basic science with potential application to kidney disease, have established collaborative scientific interactions with members of the nephrology program staff, and have extensive experience in research fellowship training. Thus, individual research training programs will be tailored for each trainee based on his/her own area of interest and long-term goals. Didactic training will also be provided in cell and molecular biology and research integrity. The program is multi-disciplinary supporting trainees in several different departments and is overseen by an Advisory Committee of three prominent and experienced senior research mentors. Of 12 individuals supported during the first 10 years of this program, 5 currently hold academic positions, 4 have federally-funded research programs, 5 are still in training and 2 have entered into practice.