New CVD risk factors for lowered congitive functioning

描述：动脉高血压和高血压（BP）是主要风险 心血管疾病（CVD）和中风的因素;它们也是危险因素 因为认知功能下降除了糖尿病， 其他常见风险因素的研究相对较少，特别是 可能对环境产生不利影响的风险因素之间的相互关系 认知能力这项研究关注的是认知能力与 功能和三个主要的CVD风险因素：（1）BP，（2）高血浆总浓度 同型半胱氨酸（tHcy）;（3）ApoE e4基因型。虽然高血压是一个 认知功能降低、tHCy和Apoe的公认风险因素 e4是相对未探索的关于认知功能的变量。一 主要目标是研究个体、累积和协同 血压、tHcy水平和ApoE e4基因型对认知功能的影响 广泛的认知能力。三个次要的，但重要的， 目标是确定：（1）不利影响的程度 这三个CYD风险因素对认知功能的影响是由 存在共存的CVD风险因素（例如，吸烟;（2） 多种危险因素对认知功能的累积影响;（3） 年龄对认知功能的影响被减弱的程度， 校正BP、tHey、ApoE基因型和其他CVD危险因素。 这项研究利用了一项大型纵向研究的现有数据， 高血压和认知功能。此外，重要的新信息 关于tHey、ApoE和BP之间的关系，将通过调用 用于认知功能额外研究的纵向受试者， 利用同期、前瞻性和回顾性分析。

DESCRIPTION: Arterial hypertension and high blood pressure (BP) are major risk factors for cardiovascular disease (CVD) and stroke; they are also risk factors for lowered cognitive functioning. Except for diabetes, there have been comparatively few studies of other common risk factors, particularly with regard to interrelationships among risk factors which may adversely affect cognitive ability. This study is concerned with associations between cognitive functioning and three major CVD risk factors: (1) BP, (2) high total plasma homocysteine (tHcy), and (3) ApoE e4 genotype. Although high BP is a well-established risk factor for lowered cognitive functioning, tHcy and ApoE e4 are relatively unexplored variables with respect to cognitive functioning. A major objective is to investigate the individual, cumulative, and synergistic effects of BP, tHcy levels, and ApoE e4 genotype on cognitive functioning over a broad range of cognitive abilities. Three secondary, but important, objectives are to determine: (1) the extent to which the adverse influence of these three CYD risk factors on cognitive functioning is affected by the presence of coexisting CVD risk factors (e.g., cigarette smoking); (2) the cumulative impact of multiple risk factors on cognitive functioning; (3) the extent to which age effects on cognitive functioning are attenuated by adjustment for BP, tHey, ApoE genotype, and other CVD risk factors. The study makes use of existing data from a large longitudinal study of hypertension and cognitive functioning. Additionally, important new information about relations among tHey, ApoE, and BP will be obtained by calling back the longitudinal subjects for additional studies of cognitive functioning and making use of concurrent, prospective, and retrospective analyses.