The development of novel technologies for the design of next generation skin products

为了为个人护理部门设计新一代皮肤产品，了解生物基化合物（包括来自植物的化合物）与皮肤中存在的不同分子组合之间发生的分子相互作用是很重要的。能够促进此类测量的平台技术将解决一个长期存在的技术瓶颈，即需要建立与抗炎反应和抗衰老相关的体外筛选方法。利用尖端的增材制造方法和微流体技术，该项目旨在设计和开发新型的芯片皮肤系统。通过利用物理科学的创新，这些模型微生理环境将提供强大的、用户定义的、可重复的系统，可以与新的光谱和色谱方法相结合，用于高通量地分析植物中的活性化合物。

In order to design a new generation of skin-based products for the personal care sector it is important to understand the molecular interactions that occur between biobased compounds (including those derived from plants) with the different molecular assemblies present with skin. Platform technologies capable of facilitating such measurements would address a long-standing technological bottleneck related to the need to establish in-vitro screening methodologies related to anti-inflammatory responses and anti-ageing. Using cutting edge additive manufacturing approaches coupled with microfluidics this project aims to design and exploit novel skin-on-a-chip systems. By exploiting innovation in the physical sciences these model microphysiological environments will provide robust, user-defined, reproducible systems that can be coupled with novel spectroscopies and chromatographic approaches that can used to profile active compounds from plants in high-throughput.