CORE--GENOMIC ANALYSIS

基因组分析核心将为密歇根大学胡椒中心的科学家提供获得遗传资源的途径，并将加强遗传信息与老年人衰老过程和健康研究的联系。该中心将协助研究衰老基础科学的中心研究人员，并为人类遗传学研究提供基础。基因组分析核心有四个具体目标： 目的1.为中心研究人员提供基因分型服务支持。核心将执行简单的 序列长度多态和单核苷酸多态检测。核心将拥有 提供预先测试的小鼠和人类基因分型基因座，并将开发定制的基因分型程序。 目标2.提供基因组分析、生物统计学和数据处理基础设施和支持。这个 CORE将开发和使用遗传分析工具进行数量性状基因座基因组搜索，以及连锁和关联研究。该中心将为遗传和表型信息的数据管理提供一个中心位置。核心人员将在基因数据处理、统计分析和实验设计方面提供专家建议。 目的3.为人类遗传学项目的评估和发展提供基础设施。这个 CORE将开发一个供老年人使用的基因研究基础设施。将提供人口结构、临床数据管理、分析和主题沟通方面的咨询服务。专业人员将为基因研究提供法规、法律和道德标准方面的专业知识。 目的4.为老龄化中的新遗传学项目提供一个发展结构。核心将征集， 评估和整合核心开发项目，旨在提高中心研究人员的基因组学能力。重点将放在协调、补充或加强中心现有研究活动的开发项目上。

The Genomic Analysis Core will provide access to genetic resources for University of Michigan Pepper Center scientists, and will enhance the linking of genetic information with studies of the aging process and health of older adults. The Core will assist Center investigators studying the basic science of aging, as well as provide a foundation for human genetic studies. The Genomic Analysis Core has four Specific Aims: Aim 1. Provide genotyping service support to Center investigators. The Core will perform simple sequence length polymorphism and single nucleotide polymorphism detection. The Core will have available pre-tested mouse and human genotyping loci, and will develop custom genotype procedures. Aim 2. Provide genomie analysis, biostatistical, and data handling infrastructure and support. The Core will develop and use genetic analysis tools for quantitative trait locus genome searches, as well as linkage and association studies. The Core will provide a central location for data management of genetic and phenotypic information. Core personnel will provide expert advice on genetic data handling, statistical analysis, and experimental design. Aim 3. Provide an infrastructure for evaluation and development of human genetics projects. The Core will develop a genetic research infrastructure for use with older adults. Consultation services will be provided on population structures, clinical data management, analysis, and subject communication. Personnel will provide expertise on regulatory, legal, and ethical standards for genetic studies. Aim 4. Provide a development structure for novel genetics projects in aging. The Core will solicit, evaluate, and integrate Core Development Projects designed to improve the genomics capabilities of Center investigators. Emphasis will be placed on development projects that co-ordinate, supplement, or enhance existing research activities of the Center.