UNC-CH Mentored Clinical Research Scholar Program

描述（申请人提供）： 北卡罗来纳州大学（University of North Carolina）有着培养学术医生和牙医早期研究生涯的悠久传统。在最高级别的大学管理部门的全力投入和资源下，医学院和牙科学院的研究职业发展重点已经从基础科学发展到更多的转化和以患者为导向的研究（POR）。这一变化是由ESTA的蓬勃发展的一般临床研究中心（GCRC）计划和一个有经验的高级导师谁也是资金充足的临床研究人员的大干部的存在刺激。因此，自三年前该计划成立以来，麻省理工学院的初级教师成功地竞争了由NIH资助的K23奖项的4%以上。这些K23与五个NCRR支持的CAP奖项相结合，为正在进行POR的初级教师的质量提供了令人信服的证据。然而，这在职业发展的显着成功，现在严重威胁到日益增加的临床需求和国家预算危机，已产生显着减少拨款给大学。由于这些原因，系主任和部门负责人很难保证年轻教师的研究时间受到保护，除非他们对这些活动有外部支持。这个应用程序，描述了这个K12奖将如何通过提供那些致力于POR职业生涯的年轻人所需的“桥梁”资金来解决这一需求。还介绍了正式系统，将用于确定和支持最有前途的个人，为期最多（但不超过）三年。在这段受保护的时间内，每位学者将接受必要的培训，收集必要的初步数据，然后撰写并提交个人职业发展奖的最佳申请。这里提出的培训计划涵盖了全方位的POR研究，包括人类疾病的机制，治疗干预，临床试验和新技术的开发，包含了新的教学元素，完全整合到现有的和非常成功的K30，BIRWCH（K12）和GCRC培训计划中。每位学者将与一位首席导师密切合作，开发和实施个人研究项目。此外，所有学者都可以使用GCRC的咨询资源，包括生物统计学，信息学和最近成立的研究主题倡导办公室。如果获得资助，这个K12奖将使申请人能够保持他们目前在POR职业发展方面的势头，因为他们寻求实现为国家培养新一代学术科学家的最终目标，他们都坚定地致力于POR。

DESCRIPTION (Provided by the applicant): The University of North Carolina (UNC) has a long tradition of nurturing the early research careers of academic physicians and dentists. With the full commitment and resources from University administration at the highest level, much of the focus of research career development in UNC's Schools of Medicine and Dentistry has now evolved from basic science toward more translational and patient-oriented research (POR). This change has been spurred on by UNC's thriving General Clinical Research Center (GCRC) program and by the presence of a large cadre of experienced senior mentors who are also well-funded clinical investigators. As a result, junior faculty members at UNC have competed successfully for more than 4% of the K23 awards that have been funded by the NIH since the inception of this program three years ago. These K23s combined with five NCRR-supported CAP awards provide convincing evidence of the quality of the junior faculty members who are conducting POR. However, this remarkable success in career development is now seriously threatened by increasing clinical demands and by a state budget crisis that has produced significant reductions in allocations to the University. For these reasons, it has become every difficult for Department Chairs and Division Chiefs to assure protected research time to junior faculty members unless they have external support for these activities. This application, describes how this K12 award would address this need by providing the "bridge" funds needed by those young people who are committed to careers in POR. Also described is the formal systems that will employed to identify and support the most promising individuals for a period of up to (but no more than) three years. During this protected time, each Scholar will receive the requisite training, collect the essential preliminary data, and then compose and submit the best possible application for an individual career development award. The training program proposed here, which embraces the full spectrum POR research, including mechanisms of human disease, therapeutic interventions, clinical trials, and development of new technologies, contains new didactic elements fully integrated into existing and highly successful K30, BIRWCH (K12), and GCRC training programs. Each scholar will work closely with a Lead Mentor to develop and implement an individual research project. In addition, all Scholars will have at their disposal the consultative resources of the GCRC, including biostatistics, informatics, and the recently established Office of Research Subject Advocacy. If funded, this K12 award will allow the applicants to maintain their current momentum in POR career development as they seek to attain the ultimate goal of seeding the country with a new generation of academic scientists, all of whom are firmly committed to POR.