Building Research Capacity in Neuroscience

描述（由申请人提供）：本拟议计划的总体目标是：1。继续支持田纳西州立大学生物科学系教师的神经科学生物医学研究。2.促进和扩大大津大学教师与纳什维尔研究界内外的研究教师的生物医学合作：a.扩大梅哈里医学院和范德比尔特大学的研究合作，以及，B。在大津的生物科学系和化学系发展合作并组建研究小组。3.提高生物医学研究能力和生产力，这将使大津建立一个卓越的神经科学研究中心。4.加强研究基础设施，这将支持和巩固教师的生物医学研究活动。第一个目标将通过支持四名教员的生物医学研究活动和继续第一个赠款期间建立的指导关系来实现。这四位教师在神经科学方面有共同的兴趣和研究训练。在第一个赠款期间，与Meharry医学院的Townsel实验室形成了强有力的合作研究。一个真正的研究合作已经形成，该小组作为一个研究团队的功能。这一努力非常成功，并在此更新申请中得到支持。该小组的研究实力将得到加强（研究技术人员;新的合作），研究生产力将衡量其成功与否。此外，RIMI将支持所有合作关系的延续（RIMI教师不包括在这里; MBRS / SCORE教师与研究密集型教师）。这些活动支持目标1、2a和3。目前，生物系和化学系之间正在开展研究合作。RIMI将尝试复制具有高水平互动的研究小组，从而提高生产力。这些将涉及一些MBRS / SCORE教师与RIMI教师。这一目标的实现将取决于项目主任强有力的科学领导。这将有助于他指导这两个项目。大津教师将组成一个互动小组。将定期举行互动会议，交流想法和经验，促进合作，扩大小组。最终目的是组建其他研究小组。至少，一个额外的研究密集组将在此奖项期间启动。这些活动支持具体目标2b和3。 这个拟议的计划，与生物科学系，将增加一个额外的教员谁将加入神经科学组。这名新教师将在今年3月初加入。这一增加将带来深度和增加生物学研究工作的重点。一个精心挑选的研究人员将增加我们的努力，以提高生产力水平，需要启动一个研究中心在神经科学（这项活动支持具体目标#3）的基础设施部分将翻新空间在博斯韦尔科学复杂的建立和装备两个新的实验室分子生物学和组织培养的目的。这些设施是必要的，本文所述的每个合作研究项目的成功。其他RIMI教师和一些MBRS / SCORE教师也将使用这些设施。这些新设施将大大增加生物科学和化学部门的研究能力。这两个实验室对两个部门都有意义。在生物科学中，细胞和分子生物学的研究能力是该部门的重点，并对博士学位有直接影响。最近启动的一个项目。在化学领域，抗癌和抗艾滋病药物的研究正在发展。一个组织培养实验室将是一个伟大的除了这些努力。这些新设施和设备支持具体目标4。这个拟议的RIMI计划将由一个由项目主任（PD; 25%）和主任助理（100%）组成的办公室指导和管理。PD将提供强有力的领导，以确保该计划保持在课程上，研究目标得到满足，并满足研究人员和合作导师的需求，如该计划所提供的。此外，PD在这些活动中有共同的研究兴趣和个人研究参与。这将大大增强他的领导能力，并大大增加RIMI计划成功的机会。

DESCRIPTION (provided by applicant): The overall objectives of this proposed program are to: 1. Continue support of biomedical research in neuroscience of faculty in the Department of Biological Sciences at Tennessee State University. 2. Promote and expand biomedical collaborations of TSU faculty with research faculty within the Nashville research community and beyond through: a. expansion of research collaborations at Meharry Medical College and Vanderbilt University and, b. development of collaborations and formation of research groups in the Department of Biological Sciences and the Department of Chemistry at TSU. 3. Improve biomedical research capacity and productivity, which will permit TSU to establish a research center of excellence in neuroscience. 4. Enhance research infrastructure, which will support and undergird the biomedical research activities of faculty. The first objective will be accomplished through the support of biomedical research activities of four faculty members and the continuation of mentoring relationships established during the first grant period. The four faculty members have a common interest and research training in neuroscience. During the first grant period a strong collaborative research effort was formed with the Townsel laboratory at Meharry Medical College. A true research collaboration has been formed and the group functions as a research team. The effort was quite successful and is supported in this renewal application. The research strength of the group will be increased (research technician; new collaborations) and research productivity will measure its success. Additionally, RIMI will support the continuation of all collaborative relationships (RIMI faculty not included here; MBRS / SCORE faculty with research intensive faculty). These activities support objectives 1,2a and 3. There are currently research collaborations being developed between biology faculty and chemistry faculty. RIMI will attempt to duplicate research groups that have high levels of interaction that leads to increased productivity. These will involve some MBRS / SCORE faculty with RIMI faculty. Accomplishment of this objective will depend on strong scientific leadership by the Program Director. It will be facilitated by the fact that he directs both programs. The TSU faculty will form an interactive group. Regular interactive meetings will be held to exchange ideas and experiences, to promote collaborations, and to expand the group. The ultimate aim is to form other research groups. Minimally, one additional research intensive group will be initiated during the period of this award. These activities support specific aims 2b and 3. This proposed program, in conjunction with the Department of Biological Sciences, would add one additional faculty member who will join the neuroscience group. This new faculty member will be added at the beginning of year 3. This addition will bring depth and increased focus to the research effort in biology. A carefully chosen researcher will increase our effort to raise the productivity level to that needed to initiate a research center in neuroscience (this activity supports specific aim #3) The infrastructure component will renovate a space in Boswell Science Complex to build and equip two new laboratories for molecular biology and tissue culture purposes. These facilities are necessary for the success of each of the collaborative research projects described herein. Other RIMI faculty and some MBRS / SCORE faculty will use the facilities also. These new facilities will significantly add to the research capacity of the departments of Biological Sciences and Chemistry. Both laboratories are of interest to both departments. In Biological Sciences research capacity in cellular and molecular biology is the focus of the department and has direct implications for the Ph.D. program that was recently initiated. In Chemistry a focus in anti-cancer and anti-AIDS drugs research is developing. A tissue culture laboratory will be a great addition for these efforts. These new facilities and equipment support specific aim 4. This proposed RIMI program will be directed and administered by an office consisting of the Program Director (PD; 25%) and an Assistant to the Director (100%). The PD will provide strong leadership to assure that the program stays on course, that research goals are met, and that the needs of research faculty and collaborating mentors as provided by the program are met. Moreover, the PD has a common research interest and personal research involvement in these activities. This will add considerable strength to his leadership and significantly increase chances for the success of the RIMI program.