Sleep Research with Digital Video Technologies

描述(申请人提供)：该小鼠为研究睡眠/觉醒调节、睡眠提供了一个极好的遗传模型。动态平衡和睡眠与昼夜节律之间的相互作用。对小鼠睡眠状态的研究最终可能为人类睡眠的控制提供洞察力。对小鼠品系的睡眠进行完整的表型描述对于睡眠/觉醒控制的遗传分析是必要的。睡眠研究一直受到技术限制的困扰，因为根据脑电和肌电活动识别睡眠一直是研究啮齿动物睡眠的主要技术。使用脑电和肌电进行睡眠分析的另一种选择是使用关于啮齿动物活动或行为的视觉观察数据。将这种视觉观察过程自动化将是睡眠研究领域的一个重要里程碑。因此，我们建议开发方法和设计算法来自动化监测和分析啮齿动物的睡眠过程、睡眠中和睡眠后的行为，以促进睡眠研究。这项拟议的研究将涉及睡眠相关行为的确定、自动化算法设计以及包括视频、脑电和肌电在内的多模式信号的相关性分析。从商业角度来看，开发一种对睡眠/清醒状态进行评分的视频分析系统将扩展Clear Sys Inc.视频分析系统的能力。这一视频分析系统将帮助快速开发和分析睡眠障碍的新疗法，目前这一行业价值数千万美元。

DESCRIPTION (provided by applicant): The Mouse provides an excellent genetic model for the study of sleep/wake regulation, sleep. Homeostasis and the interaction between sleep and circadian processes. Study of sleep states in mice may ultimately provide insight into the control of sleep in humans. A complete phenotypic description of sleep in mouse strains is necessary for the genetic analysis of sleep/wake control. Sleep research has been plagued with technological limitations because identifying sleep from EEG and EMG activity has been the primary technique used to study sleep in rodents. An alternative to using EEG and EMG for sleep analysis involves using visual observational data about the activities or behaviors of rodents. Automating such visual observation processes will be an important landmark in the field of sleep research. Therefore, we propose to develop methodologies and design algorithms to automate the monitoring and analysis of rodents' behaviors proceeding, during, and following sleep in order to facilitate sleep research. This proposed study would involve the determination of sleep-related behaviors, automated algorithm design, and the correlated analysis of multi-modal signals including video, EEG, and EMG. From a commercial perspective, the development of a video analysis system to score sleep/wake states will expand the capabilities of the Clever Sys Inc video analysis system. This video analysis system will assist the rapid development and analysis of novel treatments of sleep disorders, tens of millions dollar industry at present.