Evaluation of Novel Pyrrolo/Iminoquinone Antimalarial Compounds

开发新的抗疟疾药物是一项尚未实现的全球卫生优先事项。在这个项目中，我们将研究已被发现具有良好的体外抗疟疾活性的新化合物。我们将对这些化合物进行修饰，使其更像药物，并通过疟疾动物模型在体内评估它们的疗效。这些研究有可能确定可能导致疟疾的新疗法的化合物，疟疾是世界上最重要的热带传染病。

The development of new antimalarial drugs is an unmet global health priority. In this project we will investigate novel compounds that have been found to display promising in vitro antimalarial activity. We will modify these compounds to make them more drug-like, and assess their efficacy in vivo using malaria animal models. These studies have the potential to identify compounds that may result in a new therapy for malaria, the worlds' most significant tropical infectious disease.