Shedding of HIV In Semen Despite Antiretroviral Therapy

描述（由申请人提供）：这是一份申请面向患者研究（K24）的职业中期奖的申请，申请对象是Lee H. Harrison，医学博士，匹兹堡大学医学院和公共卫生研究生院的医学、流行病学、传染病和微生物学副教授。该申请的目标是允许候选人实质性地改变他的职业方向，增加对指导初级教师、博士生和对以患者为导向的研究感兴趣的传染病研究员的重视。具体来说，这个K24奖将允许哈里森博士：1)为医学院的传染病研究员和初级教师、公共卫生研究生院的博士生和巴西的初级研究人员提供以患者为导向的研究指导；2)与候选人指导的一名初级教师合作，开展一项研究，以确定接受高活性抗逆转录病毒治疗的艾滋病毒感染者精液中HIV RNA持续释放的因素；3)建立候选人最近在匹兹堡大学建立的传染病流行病学研究单位的研究。该单位的重点是巴西艾滋病毒感染的流行病学和预防，以及流行病学、分子流行病学和预防疫苗可预防和耐药的侵袭性细菌感染。候选人在这两个研究领域都有成功的出版和指导记录。该奖项将允许哈里森博士在他指导的各种研究项目中实质性地改变他的日常角色。保护时间的增加将导致研究效率的提高，特别是因为它将为指导匹兹堡大学下一代以患者为导向的研究人员提供保护时间。

DESCRIPTION (provided by applicant): This is an application for a Midcareer Award for Patient-Oriented Research (K24) for Lee H. Harrison, M.D., Associate Professor of Medicine, Epidemiology, and Infectious Diseases and Microbiology at the University of Pittsburgh School of Medicine and Graduate School of Public Health. The goal of this application is to allow the candidate to substantially change the direction of his career, with an increased emphasis on mentoring junior faculty, doctoral students, and infectious diseases fellows interested in pursuing careers in patient-oriented research. Specifically, this K24 award will allow Dr. Harrison to: 1) provide mentoring in patient-oriented research to infectious diseases fellows and junior faculty in the School of Medicine, doctoral students in the Graduate School of Public Health, and junior investigators from Brazil, 2) in collaboration with a junior faculty member mentored by the candidate, conduct a study to identify factors for persistent shedding of HIV RNA in semen among HIV-infected persons taking highly-active antiretroviral therapy, 3) build the research of the Infectious Diseases Epidemiology Research Unit, which the candidate recently established at the University of Pittsburgh. The focus of the unit is the epidemiology and prevention of HIV infection in Brazil and the epidemiology, molecular epidemiology, and prevention of vaccine-preventable and drug-resistant invasive bacterial infections. The candidate has a successful track record of publication and mentoring in both of these areas of research. This award will allow Dr. Harrison to substantially change his day-to-day role on a variety of research projects he directs. The increase in protected time will lead to an increase in research productivity particularly because it will provide protected time for mentoring the next generation of patient-oriented investigators at the University of Pittsburgh.