Normal Human and Schizophrenic Brain

描述：（由申请人提供）已提出精神分裂症是 这是大脑偏侧化的结果， 人类语言的进化。在正常和 精神分裂症患者大脑颞叶的大小和偏侧化。最 然而，工作集中在总体结构上，而忽视了 可能存在解剖学差异， 细胞结构区此外，研究一下 与已知功能意义相关的解剖学成分。这样的 结构是微柱，一个基本的解剖和生理单位， 大脑皮层已经证明，在以下两种情况下， 小的架构区域，反映输入，输出和局部的变化 organization.出于这个原因，它被选为理想的解剖标记， 对不对称差异的调查。在初步研究中，我们 检查了11例正常和5例正常人微柱的5个形态学特征 精神分裂的大脑结果表明：（1）正常人与正常人之间的差异 而精神分裂症患者的大脑并不是在水平方向上 细胞柱内化的细胞柱的结构，和2）不对称的 细胞列涉及一个以上的解剖变量。该项目将 检查微柱偏侧模式的可能差异， 40例患者的选定皮质区域，包括韦尼克语言区的一部分， 来自Runwell III收集的正常和52个精神分裂症脑。 将对板层III中Nissl染色细胞柱的放大图像（1100 x）进行分析。 通过强大的计算机成像硬件和软件进行分析， 研究人员精确地量化细胞柱形态的细节。如果 这项研究的初步结果得到证实，他们将证明， 报道的精神分裂症患者颞叶的差异不仅包括 也是对基本功能单位的重组。另一个可能 结果是颞叶中的微柱数量可能不同， 而不伴随着结构重组的变化。

DESCRIPTION: (provided by applicant) It has been proposed that schizophrenia is a consequence of the lateralization of the brain in conjunction with the evolution of human language. Differences have been found between normal and schizophrenic brains in the size and lateralization of temporal lobes. Most work, however, has concentrated on gross structures while ignoring the potential for anatomical differences that may be found in relevant cytoarchitectonic areas. Furthermore, it would be profitable to examine anatomical components that correlate with known functional significance. Such a structure is the minicolumn, a fundamental anatomical and physiological unit of the cortex. The morphology of the minicoiumn has been shown to differ between small architectonic regions, reflecting variation in input, output, and local organization. For this reason, it was chosen as the ideal anatomical marker for the investigation of asymmetrical differences. In our preliminary studies, we examined five morphological features of minicolumns in 11 normal and 5 schizophrenic brains. The results revealed that: 1) differences between normal and schizophrenic brains are found not in the horizontal spacing that separate cell columns internalized structure of the cell columns, and 2) asymmetry of cell columns involves more than one anatomical variable. This project will examine possible differences in lateralization patterns of minicolumns in selected areas of cortex, including a part of Wernicke's language area, in 40 normal and 52 schizophrenic brains derived from the Runwell III collection. Magnified images (1 100x) of Nissl-stained cell columns in Lamina III will be analyzed by powerful computer imaging hardware and software enabling researchers to precisely quantify details of cell column morphology. If the preliminary findings of this study are confirmed, they will demonstrate that the reported differences of the temporal lobe in schizophrenia involve not only size but also a reorganization of a basic unit of function. Another possible outcome is that the number of minicolumns in the temporal lobe may differ without a concomitant change in the structural reorganization.