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Genetics of Attention Deficit Hyperactivity Disorder

Genetics of Attention Deficit Hyperactivity Disorder
注意力缺陷多动障碍的遗传学
批准号:
6830467
负责人:
Maximilian Muenke
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
注意缺陷多动障碍(ADHD)是一种受基因影响的脑部疾病,在学龄儿童中患病率为3-5%。受影响的兄弟姐妹和多代西班牙裔家庭被招募。对ADHD相关基因座的全基因组搜索已经完成。参与者要接受一系列的心理测试,并抽血进行关联分析和定位克隆研究,这些研究被用来寻找与多动症相关的基因。到目前为止,我们有15个多代西班牙裔大家庭的完整信息。对27个信息型家系的仿真研究表明,该方法具有很好的连锁检测能力。我们对多动症的下一阶段研究涉及美国多动症家庭。
英文摘要
Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder with a prevalence of 3-5% in school-age children. Affected sibling pairs and densely affected multi-generation Hispanic families have been recruited. A genome-wide search for loci linked to ADHD has been completed. Participating individuals undergo a battery of psychological tests and have blood drawn for the linkage analysis and positional cloning studies that are being used to search for genes associated with ADHD. To date, we have complete information on 15 large, multi-generation Hispanic families. Simulation studies on 27 informative pedigrees indicate excellent power to detect linkage. The next phase of our research on ADHD involves US families with ADHD.
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Beyond the reproductive tract: The future of Y chromosome research
Beyond the reproductive tract: The future of Y chromosome research
Beyond the reproductive tract: The future of Y chromosome research
GENETIC ANALYSIS OF HUMAN BRAIN DEVELOPMENT
  • 批准号:
    2502634
  • 项目类别:
  • 资助金额:
    $39.77万
  • 财政年份:
    1994
  • 负责人:
    Maximilian Muenke
  • 依托单位:
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