Examining an extracellular matrix regulator required for cardiovascular development

心血管疾病（CVD）是澳大利亚最主要的死亡原因。心脏和血管的正确组装和功能需要特定的基因，但如果这些基因有缺陷，就会导致疾病。为了诊断和治疗CVD，我们必须首先了解这些基因的功能。该项目将研究具有导致CVD的遗传缺陷的小鼠模型。它将确定疾病发生的方式和原因，并研究干预CVD的潜在治疗选择。

Cardiovascular disease (CVD) is the highest cause of death in Australia. Specific genes are required for correct assembly and function of the heart and vessels but disease will result if those genes are defective. To diagnose and treat CVD, we must first understand how these genes function. This project will investigate mouse models with genetic defects resulting in CVD. It will determine how and why the diseases occur and investigate a potential therapeutic option for intervention in CVD.